Understanding Your Diagnostic Test: A Patient Guide to Laboratory Testing and What It Means for Your Health
A blood test that measures the level of 1,4-dioxane, an industrial chemical, in your serum or plasma to assess exposure.
{"This test measures 1,4-dioxane levels in your blood","It is primarily used for occupational health monitoring","1,4-Dioxane is a potential carcinogen found in certain industrial settings","The test requires a simple blood draw","Results help determine if you have been exposed to this chemical"}
Key facts at a glance
- LOINC
- 12997-3
- Short code
- 1,4-DIOX
- Synonyms
- 1,4Dioxane SerPl-mCnc
- Category
- chemistry
- Sample
- serum
- Container
- Serum separator tube (SST) or plain red top tube
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- ≥ 18 years
- Method
- Gas Chromatography-Mass Spectrometry (GC-MS) or Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
- CPT
- 84600
- SNOMED
- 415551003
- Specimen volume
- 2-5 mL of serum or plasma
- Stability
- Store at 2-8°C if analyzed within 7 days; otherwise store at -20°C or below. Avoid repeated freeze-thaw cycles.
- Hemolysis max
- 50
- Lipemia max
- 100
- Icterus max
- 20
- TAT
- 72–168 hours
- Order
- routine
This test is a laboratory analysis performed on a sample from your body, such as blood, urine, or tissue. It measures specific substances or markers that help your healthcare provider assess how your body is functioning and identify possible health problems, even before symptoms appear.
The 1,4-Dioxane blood test measures the amount of 1,4-dioxane, a synthetic industrial chemical, in your serum or plasma. 1,4-Dioxane is a clear liquid used primarily as a solvent in manufacturing processes, including chemical production, paint strippers, and some consumer products. It can enter the body through breathing, skin contact, or contaminated water.
Your doctor may order this test to screen for disease before symptoms develop, to help confirm or rule out a suspected diagnosis, to evaluate how well an organ or body system is working, or to monitor whether your current treatment plan is effective over time.
This test is most commonly performed for occupational health monitoring. It is recommended for workers in industries where 1,4-dioxane is used or produced, such as chemical manufacturing, paper processing, and certain types of printing operations. The test helps determine if you have been exposed to 1,4-dioxane and at what level. It may also be used in environmental health investigations when contamination is suspected.
The test is usually done at a clinic, hospital, or laboratory. A trained professional will collect a small sample, most often by drawing blood from a vein in your arm with a thin needle, or by asking you to provide a urine sample. The collection takes only a few minutes, and the sample is then sent for analysis.
A healthcare professional will draw a small blood sample from a vein in your arm using a needle. The blood will be collected in a special tube and sent to a laboratory for analysis. The test is simple and takes only a few minutes. No special preparation, such as fasting, is typically required unless instructed by your doctor.
Your results are compared with a reference range, which is the interval where values typically fall in healthy people. A result within that range is usually considered normal, while a value outside it may simply need further evaluation. Always discuss your results with your healthcare provider, who can interpret them in the context of your symptoms, medications, and overall health.
Your test results will show whether 1,4-dioxane was detected in your blood and at what concentration. The presence of 1,4-dioxane in your blood indicates recent exposure, as the chemical does not accumulate significantly in the body. Your healthcare provider will interpret the results based on your exposure history and occupational background. Even low levels may be significant depending on your work environment.
Reference range
Not detected or < limit of quantification. No established safe threshold for 1,4-dioxane exposure.N/A
No special preparation required. Patient should avoid exposure to products containing 1,4-dioxane prior to collection if possible. Standard phlebotomy procedures apply.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
1,4-Dioxane is classified by the International Agency for Research on Cancer (IARC) as a probable human carcinogen (Group 2A). Long-term occupational exposure has been associated with liver and kidney damage. This test is an important tool for occupational health programs to monitor workers in high-risk industries and ensure that exposure levels remain within safe limits. It can also help identify accidental or unexpected exposure incidents.
Frequently asked questions
Is 1,4-Dioxane dangerous at any level?
How long does 1,4-Dioxane stay in my blood?
Do I need to fast before this test?
What should I do if my results show exposure?
Can environmental exposure be detected by this test?
Sources
- 1
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- 4
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 10, 2026. · Read our editorial policy