Understanding Your Laboratory Test: A Patient Guide
This test measures the amount of 1,4-dioxane, an industrial chemical, in your urine to assess exposure to this potentially harmful substance.
{"1,4-Dioxane is an industrial solvent used in manufacturing","The test detects exposure through urine sample analysis","It helps monitor occupational and environmental exposure","High levels may indicate need for protective measures","1,4-Dioxane is classified as a probable human carcinogen"}
Key facts at a glance
- LOINC
- 16292-5
- Short code
- DIOXANE
- Synonyms
- 1,4Dioxane Ur-mCnc
- Category
- chemistry
- Sample
- urine
- Container
- Sterile plastic urine container (60 mL)
- Units
- N/A
- Ref low
- 0
- Ref high
- 1
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 0–120 years
- Method
- Gas Chromatography-Mass Spectrometry (GC-MS) or Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
- CPT
- 84600
- SNOMED
- 3131008
- Specimen volume
- Minimum 5 mL, preferred 10 mL
- Stability
- Store at 2-8°C if analysis within 7 days; otherwise freeze at -20°C or below. Protect from light and heat as 1,4-dioxane is volatile.
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 72–168 hours
- Order
- routine
This test is a laboratory analysis that helps your healthcare provider evaluate your overall health. It may be ordered during a routine checkup or to look into specific symptoms, and it gives your care team important information that guides medical decisions about your treatment.
The 1,4-Dioxane urine test measures how much of this industrial chemical is present in your urine. 1,4-Dioxane is a colorless liquid used as a solvent in manufacturing processes, including textile processing, paper production, and some consumer products. It can enter the body through breathing, skin contact, or contaminated water.
Your provider may order this test to screen for a medical condition, confirm or rule out a suspected diagnosis, monitor an ongoing health problem, or check how well a current treatment is working. It can also be part of preventive care, helping to detect potential health issues before symptoms appear.
This test is primarily used to monitor occupational exposure in workers who handle 1,4-dioxane in industrial settings. It may also be used to assess environmental exposure in communities near industrial sites or contaminated areas. Regular testing helps ensure exposure levels remain within safe limits.
The test is usually performed on a small sample, such as blood drawn from a vein in your arm or urine collected in a sterile cup. The sample is then sent to a laboratory, where trained technicians analyze it with specialized equipment. The procedure is typically quick and causes only minor, brief discomfort.
A urine sample is collected, typically at the end of a work shift. The sample is sent to a laboratory where specialized equipment measures the concentration of 1,4-dioxane or its metabolites. No special preparation is usually required, though you should follow any specific instructions from your healthcare provider.
Your results show whether your values fall within the expected reference range for healthy adults. Normal results usually suggest no sign of the condition being tested for, while abnormal values may point to a health issue that needs further evaluation. Always discuss your results with your healthcare provider, who can explain what they mean for you and whether follow-up testing or treatment is needed.
Results indicate the level of 1,4-dioxane exposure. Your healthcare provider will interpret results based on your exposure circumstances. Elevated levels may indicate excessive exposure requiring protective measures or workplace modifications. It's important to discuss your results with a healthcare professional familiar with occupational health.
Reference range
Not Detected or <1.0 ng/mL (laboratory-specific cutoff)N/A
Collect a clean-catch midstream urine sample. Avoid contamination from external sources. Inform laboratory of any occupational or environmental exposure history. No special preparation required.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
1,4-Dioxane is classified by the International Agency for Research on Cancer (IARC) as a Group 2A probable human carcinogen. Long-term exposure may increase the risk of certain cancers, particularly liver and nasal cancers. The test helps identify exposure before significant health effects occur, allowing for early intervention. Occupational safety limits have been established to protect workers from harmful exposure levels.
Frequently asked questions
Is this test painful?
How long does it take to get results?
Do I need to fast before the test?
What happens if my results are elevated?
Sources
- 1ATSDR - 1,4-DioxaneSource
- 2EPA - 1,4-DioxaneSource
- 3LOINC Code 16292-5Source
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy