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What is this test?

The 17-Hydroxyprogesterone (17-OHP) test measures the amount of this hormone in your blood or plasma. This test is specifically performed one day after taking dexamethasone, a synthetic corticosteroid medication. Dexamethasone works by suppressing the pituitary gland's production of ACTH (adrenocorticotropic hormone), which normally stimulates the adrenal glands to produce hormones.

Why is this test performed?

This test is primarily used to help diagnose and differentiate between various adrenal gland disorders, especially congenital adrenal hyperplasia (CAH). CAH is a genetic condition where the adrenal glands cannot produce enough cortisol, leading to a buildup of 17-OHP. By taking dexamethasone before the test, doctors can see how your body responds and determine if the elevated 17-OHP is due to CAH or another condition.

How is the test done?

You will be asked to take dexamethasone (usually at night) the day before your blood test. The next day, a healthcare professional will draw a blood sample from a vein in your arm. The blood sample will be sent to a laboratory for analysis. It is important to take the dexamethasone exactly as prescribed by your doctor.

What do the results mean?

After taking dexamethasone, 17-OHP levels typically decrease in people without CAH. However, in individuals with certain forms of CAH, the 17-OHP level remains elevated because the enzyme block prevents proper cortisol production. Your doctor will interpret your results based on your symptoms, medical history, and other test findings.