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17ohpamnscnc

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of 17-hydroxyprogesterone in amniotic fluid to evaluate fetal adrenal function and detect congenital adrenal hyperplasia.

Quick summary

{"Measures 17-hydroxyprogesterone hormone in amniotic fluid collected during amniocentesis","Primarily used to screen for and diagnose congenital adrenal hyperplasia (CAH) in the fetus","Helps determine if a developing baby may have a hormonal disorder affecting adrenal function","Results help doctors plan appropriate management and treatment before birth if needed","The test involves a minor procedure (amniocentesis) with small risks"}

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
69796-1
Short code
17OHP Amn-sCnc
Synonyms
17OHP Amn-sCnc
Category
chemistry
Sample
fluid
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
2-5 mL
Stability
Room temperature: 2h, Refrigerated: 24h
Hemolysis max
300
TAT
4–24 hours
Order
routine

What is this test?

The 17-Hydroxyprogesterone (17-OHP) test measures the amount of a specific hormone called 17-hydroxyprogesterone in the amniotic fluid that surrounds the baby during pregnancy. This fluid is collected through a procedure called amniocentesis, where a thin needle is used to remove a small sample of amniotic fluid from the uterus for laboratory analysis.

Why is this test performed?

This test is primarily performed to evaluate fetal adrenal gland function and to screen for or diagnose congenital adrenal hyperplasia (CAH). CAH is a genetic condition that affects the adrenal glands' ability to produce certain hormones, particularly cortisol. When a fetus has CAH, the adrenal glands may produce excess androgens (male hormones), which can affect the development of the baby's genitalia, especially in female fetuses. Early detection through this test allows healthcare providers to prepare for appropriate management and treatment after birth.

What happens during the test?

The test requires an amniocentesis procedure. During this procedure, you will lie on an examination table, and an ultrasound will be used to guide a thin needle through your abdomen and into the uterus to collect a small amount of amniotic fluid. The procedure typically takes only a few minutes. You may experience some discomfort or mild cramping during or after the procedure. The collected fluid is then sent to a laboratory where the 17-hydroxyprogesterone level is measured.

Are there any risks?

Amniocentesis carries a small risk of complications, including infection, bleeding, leakage of amniotic fluid, injury to the baby or placenta, and in rare cases, miscarriage. The overall risk of miscarriage related to amniocentesis is estimated to be very low (less than 1 in 1,000 to 1 in 500). Your healthcare provider will discuss these risks with you and help you decide if this test is appropriate for your situation.

Understanding your results

Results are reported as the concentration of 17-hydroxyprogesterone in the amniotic fluid. Higher than normal levels may suggest that the fetus has congenital adrenal hyperplasia. However, your healthcare provider will interpret the results in the context of your specific situation, including your family history, pregnancy details, and other test results. If CAH is confirmed, your healthcare team will discuss treatment options and management plans with you.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Frequently asked questions

Why would my doctor order this test?
Your doctor may order this test if you have a family history of congenital adrenal hyperplasia, if previous screening tests suggested an increased risk, or if ultrasound findings indicate possible fetal abnormalities. The test helps determine if your developing baby has CAH, which is important for planning appropriate care and treatment.
How accurate is the 17-OHP test in amniotic fluid?
The test is considered reliable for diagnosing classic forms of CAH. However, results may be affected by factors such as gestational age at the time of the procedure, laboratory methods used, and whether the sample was handled properly. Your healthcare provider will discuss the accuracy and limitations of the test with you.
What happens if the test shows elevated 17-OHP levels?
If elevated levels are detected, it suggests a high probability that the fetus has congenital adrenal hyperplasia. Your healthcare provider will discuss the findings with you and may recommend additional testing, such as genetic testing, to confirm the diagnosis. If CAH is confirmed, you will receive counseling about the condition, treatment options, and what to expect after your baby is born.
Can this test determine the sex of my baby?
While the primary purpose of this test is not to determine fetal sex, the results may provide some information related to genital development, particularly in female fetuses with CAH. However, sex determination is typically done through ultrasound or other methods.
How long does it take to get results?
The time to receive results can vary depending on the laboratory. It typically takes several days to a week or more. Your healthcare provider will inform you when results are available and will explain them to you.
  1. 1
    Mayo Clinic - Congenital Adrenal HyperplasiaSource
  2. 2
    MedlinePlus - 17-HydroxyprogesteroneSource
  3. 3
    ACOG - AmniocentesisSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy