17ohpsalscnc
A non-invasive saliva test that measures 17-hydroxyprogesterone hormone levels to assess adrenal gland function.
{"Measures hormone levels in saliva to check adrenal gland function","Mainly used to screen for and monitor congenital adrenal hyperplasia (CAH)","Saliva sample is collected at home using a simple swab technique","Results help doctors diagnose hormonal disorders","May require repeat testing for accurate diagnosis"}
Key facts at a glance
- LOINC
- 72490-6
- Short code
- 17-OHP Saliva
- Synonyms
- 17OHP Sal-sCnc
- Category
- chemistry
- Sample
- serum
- Container
- Saliva collection device (e.g., Salivette, oral swab, or passive drool collection kit)
- Units
- N/A
- Ref low
- 0.1
- Ref high
- 2.5
- Critical range
- — – 10 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 0–120 years
- Method
- Liquid chromatography-tandem mass spectrometry (LC-MS/MS) or enzyme-linked immunosorbent assay (ELISA) for quantitative determination of 17-hydroxyprogesterone in saliva
- CPT
- 83498
- SNOMED
- 314235003
- Specimen volume
- 1.0-2.0 mL of whole saliva
- Stability
- Room temperature: 24-48 hours; Refrigerated (2-8°C): 5-7 days; Frozen (-20°C or below): 2-3 months. Avoid repeated freeze-thaw cycles.
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 24–72 hours
- Order
- routine
What is this test?
The 17-Hydroxyprogesterone (17-OHP) test measures the amount of a hormone called 17-hydroxyprogesterone in your saliva. This hormone is produced by your adrenal glands, which are small glands located on top of your kidneys. 17-OHP is an important intermediate in the production of cortisol, a hormone that helps your body respond to stress, maintain blood pressure, and regulate metabolism.
Why is it performed?
This test is primarily used to: (1) Screen newborns for a genetic condition called congenital adrenal hyperplasia (CAH), which affects hormone production in the adrenal glands; (2) Monitor individuals already diagnosed with CAH to ensure treatment is working effectively; (3) Evaluate adrenal gland function in children and adults with symptoms of hormonal imbalances; (4) Help diagnose other adrenal disorders when needed.
How is the sample collected?
For a saliva test, you will be given a special collection kit. Typically, you will need to: (1) Rinse your mouth with water before collection; (2) Place a cotton swab or collection device in your mouth for 2-5 minutes to absorb saliva; (3) Place the swab in the provided container; (4) Follow specific timing instructions, as some tests require collection at certain times of day (often morning). The sample is then sent to a laboratory for analysis.
How to prepare?
Preparation may include: avoiding eating, drinking (except water), smoking, or chewing gum for 30-60 minutes before collection; not brushing teeth or using mouthwash before the test; informing your doctor about any medications you are taking, as certain drugs can affect results; following any specific instructions provided by your healthcare provider or the testing laboratory.
Reference range
Reference ranges vary by age, sex, and assay methodology. Typically: Adults: 0.5-2.5 ng/mL; Children: 0.1-1.0 ng/mL; Newborns (preterm): 1.0-10.0 ng/mL; Newborns (term): 0.5-5.0 ng/mL. Clinical interpretation should consider age, sex, and clinical context.N/A
Patient should refrain from eating, drinking (except water), smoking, or chewing gum for at least 30 minutes before sample collection. Rinse mouth with water 10-15 minutes prior to collection. Avoid topical steroid applications near the oral cavity. Collect sample preferably in the morning between 7:00-10:00 AM unless otherwise specified by provider.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Frequently asked questions
Is the saliva test as accurate as blood testing?
What do high levels mean?
Do I need to fast before this test?
How long does it take to get results?
Can this test be done at home?
Sources
- 1
- 2
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy