Skip to content

17ohpsalscnc

Published: August 9, 2026Updated: August 16, 2026

A non-invasive saliva test that measures 17-hydroxyprogesterone hormone levels to assess adrenal gland function.

Quick summary

{"Measures hormone levels in saliva to check adrenal gland function","Mainly used to screen for and monitor congenital adrenal hyperplasia (CAH)","Saliva sample is collected at home using a simple swab technique","Results help doctors diagnose hormonal disorders","May require repeat testing for accurate diagnosis"}

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
72490-6
Short code
17-OHP Saliva
Synonyms
17OHP Sal-sCnc
Category
chemistry
Sample
serum
Container
Saliva collection device (e.g., Salivette, oral swab, or passive drool collection kit)
Units
N/A
Ref low
0.1
Ref high
2.5
Critical range
— – 10 N/A
Fasting
false
Population
adult
Sex
all
Age range
0–120 years
Method
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) or enzyme-linked immunosorbent assay (ELISA) for quantitative determination of 17-hydroxyprogesterone in saliva
CPT
83498
SNOMED
314235003
Specimen volume
1.0-2.0 mL of whole saliva
Stability
Room temperature: 24-48 hours; Refrigerated (2-8°C): 5-7 days; Frozen (-20°C or below): 2-3 months. Avoid repeated freeze-thaw cycles.
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
24–72 hours
Order
routine

What is this test?

The 17-Hydroxyprogesterone (17-OHP) test measures the amount of a hormone called 17-hydroxyprogesterone in your saliva. This hormone is produced by your adrenal glands, which are small glands located on top of your kidneys. 17-OHP is an important intermediate in the production of cortisol, a hormone that helps your body respond to stress, maintain blood pressure, and regulate metabolism.

Why is it performed?

This test is primarily used to: (1) Screen newborns for a genetic condition called congenital adrenal hyperplasia (CAH), which affects hormone production in the adrenal glands; (2) Monitor individuals already diagnosed with CAH to ensure treatment is working effectively; (3) Evaluate adrenal gland function in children and adults with symptoms of hormonal imbalances; (4) Help diagnose other adrenal disorders when needed.

How is the sample collected?

For a saliva test, you will be given a special collection kit. Typically, you will need to: (1) Rinse your mouth with water before collection; (2) Place a cotton swab or collection device in your mouth for 2-5 minutes to absorb saliva; (3) Place the swab in the provided container; (4) Follow specific timing instructions, as some tests require collection at certain times of day (often morning). The sample is then sent to a laboratory for analysis.

How to prepare?

Preparation may include: avoiding eating, drinking (except water), smoking, or chewing gum for 30-60 minutes before collection; not brushing teeth or using mouthwash before the test; informing your doctor about any medications you are taking, as certain drugs can affect results; following any specific instructions provided by your healthcare provider or the testing laboratory.

Reference range

Reference ranges vary by age, sex, and assay methodology. Typically: Adults: 0.5-2.5 ng/mL; Children: 0.1-1.0 ng/mL; Newborns (preterm): 1.0-10.0 ng/mL; Newborns (term): 0.5-5.0 ng/mL. Clinical interpretation should consider age, sex, and clinical context.N/A

Specimen: serum

Patient should refrain from eating, drinking (except water), smoking, or chewing gum for at least 30 minutes before sample collection. Rinse mouth with water 10-15 minutes prior to collection. Avoid topical steroid applications near the oral cavity. Collect sample preferably in the morning between 7:00-10:00 AM unless otherwise specified by provider.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Frequently asked questions

Is the saliva test as accurate as blood testing?
Saliva testing for 17-OHP can be a reliable alternative to blood testing, particularly for monitoring purposes. However, the accuracy depends on proper sample collection and timing. Your doctor will determine which testing method is most appropriate for your situation.
What do high levels mean?
High 17-OHP levels often suggest congenital adrenal hyperplasia (CAH). However, slightly elevated levels may have other causes. Your healthcare provider will interpret your results in context with your symptoms, medical history, and other test results.
Do I need to fast before this test?
Generally, you do not need to fast for a saliva test. However, you should not eat, drink (except water), smoke, or chew gum for 30-60 minutes before collecting your saliva sample, as these can contaminate the sample.
How long does it take to get results?
Results typically take 3-7 days, depending on the laboratory. Your healthcare provider will contact you with results or discuss them at your follow-up appointment.
Can this test be done at home?
Yes, saliva sample collection for 17-OHP testing can often be done at home using a provided collection kit. However, the sample must still be sent to a certified laboratory for analysis. Follow all instructions carefully to ensure accurate results.
  1. 1
  2. 2
  3. 3

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy