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1mehistamnmcnc

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of 1-methylhistidine, a substance from muscle metabolism, in the amniotic fluid surrounding the baby during pregnancy.

Quick summary

{"1-Methylhistidine is a natural byproduct of muscle breakdown that can be measured in amniotic fluid","The test helps doctors assess fetal development and health during pregnancy","It may be used to evaluate fetal muscle maturity and detect certain metabolic conditions","The sample is collected through amniocentesis, a procedure where a small amount of fluid is removed from the womb","Results are combined with other tests to provide a complete picture of fetal health"}

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
13406-4
Short code
1Me-hist Amn-mCnc
Synonyms
1Me-hist Amn-mCnc
Category
chemistry
Sample
fluid
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
2-5 mL
Stability
Room temperature: 2h, Refrigerated: 24h
Hemolysis max
300
TAT
4–24 hours
Order
routine

What is this test?

The 1-methylhistidine test measures the amount of 1-methylhistidine in the amniotic fluid. 1-Methylhistidine is a compound produced when a muscle protein called anserine breaks down. Since anserine is found mainly in muscle tissue, measuring its byproduct can help doctors understand how well the baby's muscles are developing.

How is the sample collected?

The sample is collected through a procedure called amniocentesis. During this procedure, a thin needle is used to withdraw a small amount of amniotic fluid from the womb. The procedure is performed under ultrasound guidance to ensure safety. While amniocentesis carries a small risk of complications, it is a common diagnostic procedure performed when needed for prenatal assessment.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Frequently asked questions

Why do I need this test?
Your doctor may recommend this test if there are concerns about your baby's development, particularly muscle development or certain metabolic conditions. It helps provide important information about your baby's health before birth.
Is this test safe?
The amniocentesis procedure used to collect the sample carries a small risk of complications, including infection, bleeding, or rarely, miscarriage. Your doctor will discuss the risks and benefits with you before the procedure. Ultrasound guidance helps minimize risks.
What do the results mean?
Your doctor will interpret the results in context with other tests and your specific situation. Abnormal levels of 1-methylhistidine may warrant further investigation, but your healthcare provider will explain what the results mean for your pregnancy.
How long does it take to get results?
The time for results may vary depending on the laboratory. Your healthcare provider will inform you when to expect the results and will discuss them with you once available.
  1. 1
    LOINC Code ReferenceSource
  2. 2
    March of Dimes - AmniocentesisSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy