3ohpalmitoylcarnamnscnc
A prenatal blood test that measures C16-OH levels in amniotic fluid to screen for fetal fatty acid oxidation disorders.
{"This test measures 3-Hydroxypalmitoylcarnitine (C16-OH) levels in amniotic fluid during pregnancy","It helps screen for fatty acid oxidation disorders in the unborn baby, such as MCAD deficiency","Abnormally high levels may indicate the baby has a metabolic disorder that requires special care after birth","The test is part of newborn screening but performed during pregnancy for early diagnosis","If abnormal, doctors will discuss treatment options and delivery planning"}
Key facts at a glance
- LOINC
- 50126-2
- Short code
- 3OH-Palmitoylcarn Amn-sCnc
- Synonyms
- 3OH-Palmitoylcarn Amn-sCnc
- Category
- chemistry
- Sample
- fluid
- Container
- Sterile tube
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 2-5 mL
- Stability
- Room temperature: 2h, Refrigerated: 24h
- Hemolysis max
- 300
- TAT
- 4–24 hours
- Order
- routine
What is this test?
The 3-Hydroxypalmitoylcarnitine (C16-OH) test measures the amount of a specific fatty acid substance in the amniotic fluid that surrounds the baby during pregnancy. C16-OH is a type of acylcarnitine that can build up in the blood when the body cannot properly break down fats for energy. This test helps doctors determine if the unborn baby may have a fatty acid oxidation disorder.
Why is this test done during pregnancy?
This test is performed during pregnancy to screen for inherited metabolic disorders, particularly Medium-Chain Acyl-CoA Dehydrogenase (MCAD) deficiency and other fatty acid oxidation disorders. These conditions prevent the body from converting fats into energy properly. Early detection allows healthcare providers to prepare for special care needs after birth, including dietary management and avoidance of fasting, which can prevent serious complications.
How is the test performed?
During amniocentesis, a thin needle is used to collect a small sample of amniotic fluid from the womb. The sample is then sent to a laboratory where the C16-OH level is measured. The procedure is typically performed between 15-20 weeks of pregnancy, though timing may vary based on individual circumstances.
What do the results mean?
Normal C16-OH levels in amniotic fluid indicate no evidence of a fatty acid oxidation disorder. Elevated levels suggest the unborn baby may have a metabolic condition. However, follow-up testing after birth is usually needed to confirm the diagnosis. If results are abnormal, a genetic counselor or metabolic specialist will discuss the implications and create a management plan for the baby's care.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Frequently asked questions
Is this test safe for my baby?
What happens if the test shows high C16-OH levels?
Can this test detect all metabolic disorders?
Do I need to fast before this test?
What is the difference between this prenatal test and newborn screening?
Sources
- 1
- 2
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy