4q25g111720761tggenobldt

Published: August 9, 2026Updated: August 16, 2026

This test detects a specific genetic variation (4q25 g.111720761T>G) associated with increased risk of atrial fibrillation.

Quick summary

This test looks for a genetic variation that may increase heart rhythm problems risk It is performed on a blood sample collected in an EDTA tube Results help identify genetic susceptibility to atrial fibrillation A positive result means higher risk, not certainty of developing the condition Results should be discussed with a genetic counselor or cardiologist

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC: 92935-6
Short code: 4q25-111720761
Synonyms: 4q25 g.111720761T>G Geno Bld/T
Category: chemistry
Sample: whole-blood
Container: EDTA tube (purple top) - Vacutainer tube with K2EDTA or K3EDTA anticoagulant
Units: N/A
Fasting: false
Population: adult
Sex: all
Age range: ≥ 18 years
Method: molgen
CPT: 81215
SNOMED: 1141006
Specimen volume: 2-5 mL whole blood
Stability: Room temperature (20-25°C): 7 days; Refrigerated (2-8°C): 14 days; Frozen (-20°C or below): 30 days. Avoid repeated freeze-thaw cycles.
Hemolysis max: 0
Lipemia max: 0
Icterus max: 0
TAT: 168–336 hours
Order: routine

What is this test, and why might my healthcare provider recommend it for me?

The 4q25 g.111720761T>G test is a genetic test that identifies a specific DNA variation (polymorphism) located on chromosome 4 at position q25. This particular genetic variant has been studied extensively and is associated with an increased risk of developing atrial fibrillation (AF), a common heart rhythm disorder.

How is the test performed, and what should I expect during the procedure?

A healthcare provider will collect a small blood sample from a vein in your arm. The sample is then sent to a specialized laboratory where molecular genetics techniques are used to analyze your DNA and determine whether you carry the 4q25 g.111720761T>G variant. The test result will be reported as a genotype: either heterozygous (one copy) or homozygous (two copies) for the variant, or wild-type (no variant detected).

What do the results mean, and how will my doctor use them to guide my care?

If the variant is detected, it indicates that you have a genetic predisposition to atrial fibrillation. However, having this genetic variation does not mean you will definitely develop atrial fibrillation. Many people with this variant never develop the condition, while some people without the variant still develop AF. Your overall risk depends on other genetic factors, lifestyle, age, and other medical conditions.

Reference range

Reference range is reported as genotype: Ref/Ref (wild type/homozygous reference), Het (heterozygous), or Hom (homozygous variant). The presence of the 4q25 g.111720761T>G variant is reported as detected or not detected.N/A

Specimen: whole-blood

No special patient preparation required. Inform patient that this is a genetic test for variant detection. Genetic counseling may be recommended based on results.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

The 4q25 g.111720761T>G variant is one of the most strongly associated genetic risk factors for atrial fibrillation identified through genome-wide association studies (GWAS). Individuals carrying this variant may have a 1.4 to 1.7 times higher risk of developing AF compared to those without the variant. This information can be useful for risk stratification, early monitoring, and preventive strategies, particularly in individuals with a family history of atrial fibrillation or other risk factors such as hypertension, heart disease, or diabetes.

Frequently asked questions

Why would my doctor order this test?

Your doctor may order this test if you have a family history of atrial fibrillation, unexplained palpitations, or if you want to understand your genetic risk for heart rhythm problems. It may also be part of a broader genetic screening panel.

Does a positive result mean I will get atrial fibrillation?

No, a positive result indicates increased genetic susceptibility but does not guarantee development of atrial fibrillation. Many factors contribute to whether someone develops AF, including other genes, lifestyle factors, age, and other medical conditions.

Is genetic counseling recommended?

Yes, genetic counseling is strongly recommended before and after this test. A genetic counselor can help you understand what the results mean for your health, discuss the implications for family members, and guide you on appropriate follow-up care.

Will insurance cover this test?

Coverage varies by insurance provider and individual policy. Some insurers cover genetic testing when there is a clear medical indication, such as a family history of atrial fibrillation. It is recommended to check with your insurance company beforehand.

Sources

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy