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Synthetic Cannabinoids Test (K2/Spice Screening)

Published: August 9, 2026Updated: August 16, 2026

This test detects the presence of 5F-ADB-M7, a metabolite of synthetic cannabinoids, in urine.

Quick summary

{"5F-ADB-M7 is a metabolite of synthetic cannabinoids (man-made cannabis-like substances)","This is a confirmatory test used to verify synthetic cannabinoid use","Synthetic cannabinoids can be much more dangerous than natural cannabis","Results are reported as Present or Not Detected","This test is often used in drug testing programs and clinical settings"}

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
111505-4
Short code
5FADB-M7
Synonyms
5-F ADB-M7 Ur Ql Cfm
Category
chemistry
Sample
urine
Container
Sterile urine container (plastic, leak-proof)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
12–100 years
Method
confirm
CPT
80307
SNOMED
121817009
Specimen volume
10-30 mL preferred
Stability
Refrigerated (2-8°C) for up to 7 days; frozen (-20°C) for longer storage up to 30 days
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
24–72 hours
Order
routine

This test checks a sample of your urine for synthetic cannabinoids, sometimes called K2 or Spice. It helps your doctor find out whether you have recently used these man-made mind-altering substances, which are not detected by standard drug tests.

The 5F-ADB-M7 test is a confirmatory urine test that detects the presence of 5F-ADB-M7, which is a metabolite (breakdown product) of synthetic cannabinoids. Synthetic cannabinoids are man-made chemicals designed to produce effects similar to tetrahydrocannabinol (THC), the main psychoactive compound in natural cannabis.

A health care professional will ask you to provide a urine sample in a clean container, usually at a clinic, hospital, or laboratory. The sample is then sent to a laboratory, where it is analyzed for synthetic cannabinoids and the byproducts your body makes when breaking them down.

A urine sample is collected and sent to a laboratory for analysis. The confirmatory method used is typically mass spectrometry, which is highly accurate and can definitively identify the presence of 5F-ADB-M7. This test is more specific than initial screening tests and confirms whether synthetic cannabinoids have been used.

Synthetic cannabinoids are human-made chemicals that act on the same brain receptors as THC, the active ingredient in marijuana. They are often sprayed onto dried plant material and sold under names such as K2 or Spice, but they can be much stronger and more dangerous than natural marijuana.

Synthetic cannabinoids are laboratory-made substances that bind to the same brain receptors as THC. They are often sold as herbal products sprayed with chemicals, under brand names like "Spice," "K2," or "legal weed." These substances can be significantly more potent and dangerous than natural cannabis, with effects including severe anxiety, hallucinations, rapid heart rate, kidney damage, and in some cases, death.

A positive result means synthetic cannabinoids or their byproducts were found in your urine, which shows recent use of these substances. A negative result means none were detected in your sample. Your doctor will explain what your results mean for your health and discuss any next steps in your care.

The test result will show either "Detected" (Present) or "Not Detected." A "Detected" result indicates recent use of synthetic cannabinoids containing 5F-ADB-M7. "Not Detected" means no 5F-ADB-M7 was found in the urine sample at the time of testing.

Reference range

Not Detected (< cutoff)N/A

Specimen: urine

Collect random urine specimen in sterile container. Avoid contamination with household chemicals. Inform laboratory of any prescribed medications or supplements. No fasting required.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This test is primarily used for: (1) Confirming synthetic cannabinoid use in clinical and forensic settings, (2) Monitoring patients in substance abuse treatment programs, (3) Workplace drug testing where synthetic cannabinoids may be included in screening panels, and (4) Emergency department evaluations when synthetic cannabinoid intoxication is suspected. Synthetic cannabinoid use has been linked to mass poisonings and severe health emergencies worldwide.

Synthetic cannabinoids can remain detectable in urine for several days after use, depending on the specific compound, dose, and individual metabolism. The detection window is typically longer than for natural cannabis.

Frequently asked questions

Is this test the same as a cannabis/marijuana test?
No. This test specifically looks for synthetic cannabinoids, not natural cannabis (THC). Regular marijuana tests will not detect synthetic cannabinoids, and this test will not detect natural cannabis use.
How long can 5F-ADB-M7 be detected in urine?
Synthetic cannabinoids can typically be detected in urine for 2-7 days after use, though this varies based on frequency of use, metabolism, and the specific compound. Chronic users may have longer detection windows.
Is a positive result illegal?
The legal status of synthetic cannabinoids varies by country and jurisdiction. Many synthetic cannabinoids are legally controlled substances. This test is typically used for clinical monitoring or workplace compliance rather than legal prosecution.
Can synthetic cannabinoids show up on a standard drug test?
Most standard drug tests do not detect synthetic cannabinoids because they are designed to detect THC. Specialized testing is required to identify synthetic cannabinoid use, such as this confirmatory test.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy