Synthetic Cannabinoids Test (K2/Spice Screening)
This test detects the presence of 5F-ADB-M7, a metabolite of synthetic cannabinoids, in urine.
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Key facts at a glance
- LOINC
- 111505-4
- Short code
- 5FADB-M7
- Synonyms
- 5-F ADB-M7 Ur Ql Cfm
- Category
- chemistry
- Sample
- urine
- Container
- Sterile urine container (plastic, leak-proof)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 12–100 years
- Method
- confirm
- CPT
- 80307
- SNOMED
- 121817009
- Specimen volume
- 10-30 mL preferred
- Stability
- Refrigerated (2-8°C) for up to 7 days; frozen (-20°C) for longer storage up to 30 days
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 24–72 hours
- Order
- routine
This test checks a sample of your urine for synthetic cannabinoids, sometimes called K2 or Spice. It helps your doctor find out whether you have recently used these man-made mind-altering substances, which are not detected by standard drug tests.
The 5F-ADB-M7 test is a confirmatory urine test that detects the presence of 5F-ADB-M7, which is a metabolite (breakdown product) of synthetic cannabinoids. Synthetic cannabinoids are man-made chemicals designed to produce effects similar to tetrahydrocannabinol (THC), the main psychoactive compound in natural cannabis.
A health care professional will ask you to provide a urine sample in a clean container, usually at a clinic, hospital, or laboratory. The sample is then sent to a laboratory, where it is analyzed for synthetic cannabinoids and the byproducts your body makes when breaking them down.
A urine sample is collected and sent to a laboratory for analysis. The confirmatory method used is typically mass spectrometry, which is highly accurate and can definitively identify the presence of 5F-ADB-M7. This test is more specific than initial screening tests and confirms whether synthetic cannabinoids have been used.
Synthetic cannabinoids are human-made chemicals that act on the same brain receptors as THC, the active ingredient in marijuana. They are often sprayed onto dried plant material and sold under names such as K2 or Spice, but they can be much stronger and more dangerous than natural marijuana.
Synthetic cannabinoids are laboratory-made substances that bind to the same brain receptors as THC. They are often sold as herbal products sprayed with chemicals, under brand names like "Spice," "K2," or "legal weed." These substances can be significantly more potent and dangerous than natural cannabis, with effects including severe anxiety, hallucinations, rapid heart rate, kidney damage, and in some cases, death.
A positive result means synthetic cannabinoids or their byproducts were found in your urine, which shows recent use of these substances. A negative result means none were detected in your sample. Your doctor will explain what your results mean for your health and discuss any next steps in your care.
The test result will show either "Detected" (Present) or "Not Detected." A "Detected" result indicates recent use of synthetic cannabinoids containing 5F-ADB-M7. "Not Detected" means no 5F-ADB-M7 was found in the urine sample at the time of testing.
Reference range
Not Detected (< cutoff)N/A
Collect random urine specimen in sterile container. Avoid contamination with household chemicals. Inform laboratory of any prescribed medications or supplements. No fasting required.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
This test is primarily used for: (1) Confirming synthetic cannabinoid use in clinical and forensic settings, (2) Monitoring patients in substance abuse treatment programs, (3) Workplace drug testing where synthetic cannabinoids may be included in screening panels, and (4) Emergency department evaluations when synthetic cannabinoid intoxication is suspected. Synthetic cannabinoid use has been linked to mass poisonings and severe health emergencies worldwide.
Synthetic cannabinoids can remain detectable in urine for several days after use, depending on the specific compound, dose, and individual metabolism. The detection window is typically longer than for natural cannabis.
Frequently asked questions
Is this test the same as a cannabis/marijuana test?
How long can 5F-ADB-M7 be detected in urine?
Is a positive result illegal?
Can synthetic cannabinoids show up on a standard drug test?
Sources
- 1
- 2
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy