Understanding Your Laboratory Blood Test: A Patient Guide to Testing, Procedure, and Results
This test detects 6-monoacetylmorphine (6-MAM), a specific breakdown product of heroin, in your urine to determine recent heroin use.
{"6-MAM is a unique marker only produced when the body processes heroin","This test can detect heroin use within 2-4 days after use","A positive result indicates recent heroin use","The test uses urine sample and is a screening method only","Confirmation testing may be needed for legal or employment purposes"}
Key facts at a glance
- LOINC
- 19321-9
- Short code
- 6MAM
- Synonyms
- 6MAM Ur Ql Scn
- Category
- chemistry
- Sample
- urine
- Container
- Sterile urine collection cup or sterile urine transport tube
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- ≥ 0 years
- Method
- screen
- CPT
- 80307
- SNOMED
- 373435004
- Specimen volume
- 10-30 mL preferred; minimum 5 mL
- Stability
- Room temperature (20-25°C): 24-48 hours; Refrigerated (2-8°C): 5-7 days; Frozen (-20°C or below): 30 days. Transport to laboratory promptly.
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 24–72 hours
- Order
- routine
This laboratory test measures important substances in your blood to help your healthcare provider evaluate your overall health, screen for certain medical conditions, and make informed decisions about your ongoing care and treatment plan.
The 6-Monoacetylmorphine (6-MAM) test is a urine screening test that detects the presence of 6-MAM, which is a specific metabolite (breakdown product) of heroin. When heroin enters the body, it is quickly metabolized into 6-MAM, which can be detected in urine. This is different from other opioid tests because 6-MAM is only produced from heroin—not from prescription pain medications like morphine or codeine.
A trained healthcare professional will clean a small area of your skin, usually on the inside of your elbow, and draw a small sample of blood into a collection tube. The sample is then sent to a laboratory for analysis, and the entire procedure typically takes only a few minutes.
A urine sample is collected in a clean container. The sample is then analyzed using screening methods (immunoassay) to detect the presence of 6-MAM. If the screening test is positive, confirmation testing (such as gas chromatography-mass spectrometry) may be performed to verify the result.
Your results will be compared with established reference ranges. Values within the normal range generally suggest typical organ function, while values that are higher or lower than normal may indicate an underlying condition that requires further evaluation and follow-up with your healthcare provider.
A 'Presence' result means that 6-MAM was detected in your urine, indicating recent heroin use (typically within 2-4 days). A 'Not Detected' result means no 6-MAM was found in the sample. It's important to note that this is a screening test, and positive results may need confirmation with more specific testing methods.
Reference range
Negative - Not DetectedN/A
No special preparation required. Patient should provide a clean catch urine sample. Inform the patient that this is a drug screen test. Maintain proper chain of custody following facility protocols.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
This test is primarily used to monitor for heroin use in patients undergoing substance abuse treatment, for workplace drug testing, or in legal/forensic settings. The presence of 6-MAM is considered definitive proof of heroin use because it is not produced by any other substance. Healthcare providers may use this test to assess treatment compliance, determine the need for intervention, or evaluate patients with suspected opioid overdose.
Frequently asked questions
How long after heroin use can 6-MAM be detected?
Will prescription pain medications cause a positive result?
Can this test be used for employment screening?
Is the test confidential?
Sources
- 1
- 2
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy