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7-Dehydrocholesterol, Amniotic Fluid — Substance Concentration

Published: August 9, 2026Updated: August 16, 2026

Measures 7-dehydrocholesterol in amniotic fluid to help evaluate for certain inherited disorders of cholesterol synthesis, including Smith-Lemli-Opitz syndrome.

Quick summary

["Elevated 7-dehydrocholesterol in amniotic fluid may indicate an inherited cholesterol-synthesis disorder."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
46700-1
Short code
7-DHC Amn-sCnc
Synonyms
7-DHC Amn-sCnc
Category
lipid
Sample
fluid
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
2-5 mL
Stability
Room temperature: 2h, Refrigerated: 24h
Hemolysis max
300
TAT
4–24 hours
Order
routine

What is this test?

This test measures the concentration of 7-dehydrocholesterol, a substance formed during cholesterol production, in amniotic fluid. It is used in specialized prenatal evaluations for disorders affecting cholesterol synthesis.

Why might I need this test?

The test may be considered if prenatal screening suggests Smith-Lemli-Opitz syndrome or another condition that affects cholesterol production. It may also be ordered when there is a family history of an inherited cholesterol-synthesis disorder.

How is the test performed?

A laboratory analyzes an amniotic fluid sample collected by amniocentesis. The report provides the measured concentration of 7-dehydrocholesterol for interpretation by your healthcare professional.

How do I prepare for the test?

No special diet or fasting is usually required for the laboratory measurement itself. Preparation and follow-up care depend on the amniocentesis procedure and the instructions provided by your prenatal care clinician.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

7-Dehydrocholesterol (Amniotic Fluid)

Frequently asked questions

What does 7-dehydrocholesterol measure?
It measures a compound involved in the body's cholesterol-production pathway. The test estimates how much is present in a given volume of amniotic fluid.
Does this test require an amniocentesis?
The test uses amniotic fluid, which is obtained through amniocentesis. Your prenatal clinician can explain the procedure, risks, and timing.
Does an abnormal result confirm a genetic disorder?
No. An abnormal result may raise suspicion for a cholesterol-synthesis disorder but generally requires confirmation with genetic testing and clinical evaluation.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy