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Alpha-1 Antitrypsin, Serum/Plasma — Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

Measures the amount of alpha-1 antitrypsin protein in blood to help evaluate inherited alpha-1 antitrypsin deficiency and related liver or lung conditions.

Quick summary

["This blood test measures alpha-1 antitrypsin, a protein that helps protect the lungs and liver."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
1828-3
Short code
A1AT MZ SerPl-mCnc
Synonyms
A1AT MZ SerPl-mCnc
Category
liver
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

This test measures the concentration of alpha-1 antitrypsin in serum or plasma. Alpha-1 antitrypsin is a protein made mainly by the liver that helps prevent damage to lung tissue.

Why might I need this test?

A healthcare professional may order this test when an inherited alpha-1 antitrypsin deficiency is suspected, especially in people with unexplained liver disease, chronic lung disease, or a family history of the condition.

How is the test performed?

A blood sample is collected, usually from a vein in the arm. The laboratory measures the amount of alpha-1 antitrypsin in the serum or plasma using a validated testing method.

How do I prepare for the test?

No special preparation is usually needed. Tell your healthcare professional if you have an acute illness, liver disease, or are taking medicines that may affect the alpha-1 antitrypsin level, because these factors can influence the result.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Alpha-1 antitrypsin test

Frequently asked questions

What does alpha-1 antitrypsin do?
Alpha-1 antitrypsin is a protective protein that helps limit inflammation and damage in the lungs. It is produced primarily by the liver.
Does a low result mean I have alpha-1 antitrypsin deficiency?
A low result can suggest deficiency, but it does not confirm the diagnosis by itself. Your healthcare professional may recommend additional blood tests or genetic testing.
Can illness or medicines affect the result?
Yes. Acute inflammation, liver disease, and certain medicines can alter alpha-1 antitrypsin levels. Your healthcare professional will interpret the result in your clinical context.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy