Alpha-1 Antitrypsin, Stool — Mass Content

What is this test?

Fecal alpha-1 antitrypsin testing measures the amount of a small blood protein called alpha-1 antitrypsin in your stool. Alpha-1 antitrypsin is normally present in the bloodstream, so increased amounts in the stool can suggest protein loss through the digestive tract.

Why might I need this test?

Your clinician may order this test if you have symptoms such as swelling, unexplained weight loss, diarrhea, or other signs of protein loss. It can help investigate disorders that allow blood proteins to leak into the intestines, a condition sometimes called protein-losing enteropathy.

How is the test performed?

A stool sample is collected and sent to a laboratory. The laboratory measures the amount of alpha-1 antitrypsin in the sample and reports the result in a form that can be interpreted alongside your symptoms and other test findings.

How do I prepare for the test?

Follow your clinician's instructions for collecting the stool sample, including any timing, container, and storage requirements. Tell the laboratory if the sample was collected during active bleeding, because blood in the stool can affect the result. Fasting is usually not required unless your clinician gives specific instructions.