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Alpha-1 Antitrypsin, Serum/Plasma — Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

Measures the amount of alpha-1 antitrypsin in blood to help evaluate inherited deficiency and certain lung or liver conditions.

Quick summary

["This blood test measures alpha-1 antitrypsin, a protein that helps protect the lungs and liver."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
1830-9
Short code
A1AT SZ SerPl-mCnc
Synonyms
A1AT SZ SerPl-mCnc
Category
liver
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

This test measures the concentration of alpha-1 antitrypsin, a protective protein made by the liver, in a blood sample. The protein helps limit inflammation and damage in the lungs and liver.

Why might I need this test?

A provider may order this test for unexplained chronic cough, shortness of breath, emphysema, or liver disease. It may also be used to investigate a family history of alpha-1 antitrypsin deficiency or monitor someone with a known low level.

How is the test performed?

A blood sample is collected and separated into serum or plasma. A laboratory then measures the alpha-1 antitrypsin concentration using a validated testing method.

How do I prepare for the test?

Fasting is usually not required, but follow any instructions from your healthcare provider. Tell the laboratory about medicines and supplements you take because some can affect protein measurements or interfere with certain assays.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Alpha-1 antitrypsin level

Frequently asked questions

Does this test require fasting?
Usually not. Follow your provider's instructions, and ask the laboratory whether any medicines or supplements should be held before testing.
What does a low alpha-1 antitrypsin level mean?
It may indicate an inherited deficiency, although other factors can affect the measurement. Your provider will interpret the result alongside your symptoms, family history, and other tests.
Can inflammation cause a high result?
Yes. Alpha-1 antitrypsin can rise during inflammation, infection, pregnancy, or with certain medications, so an elevated result does not always indicate a genetic disorder.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy