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Alpha-2 Laminin Antigen, Tissue — Qualitative Immunostain

Published: August 9, 2026Updated: August 16, 2026

A qualitative tissue test that detects alpha-2 laminin in a biopsy using immunohistochemical staining. Pathologists use it to assess laminin alpha-2 expression.

Quick summary

["This test checks whether alpha-2 laminin is present in a tissue sample and is interpreted by a pathologist."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
42660-1
Short code
A2 Laminin Ag Tiss Ql ImStn
Synonyms
A2 Laminin Ag Tiss Ql ImStn
Category
liver
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
immune-stain
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

Alpha-2 laminin is a protein found in the basement membrane, which supports many tissue cells. This qualitative test uses special staining to show whether alpha-2 laminin is present in a tissue specimen.

Why might I need this test?

A clinician may order this test when examining a biopsy, often of muscle, to evaluate alpha-2 laminin expression. It may help characterize certain inherited muscle and connective-tissue conditions.

How is the test performed?

A tissue sample collected by biopsy is processed in the laboratory. The pathologists use immunohistochemical staining to highlight alpha-2 laminin and then evaluate the staining pattern.

How do I prepare for the test?

Preparation depends on the biopsy procedure and the reason for testing. Follow your clinician's instructions, including any fasting, medication, or timing requirements for the biopsy.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Reduced or absent alpha-2 laminin staining may indicate decreased expression of this basement-membrane protein and can support certain muscular dystrophy or connective-tissue disorders. Unusual staining patterns may have other causes and require clinical and microscopic correlation. A pathologist interprets the result together with the specimen type and other test findings.

Short name

Alpha-2 laminin tissue immunostain

Frequently asked questions

Is this a blood test?
No. This test is performed on a tissue specimen, usually obtained by biopsy.
What does a positive result mean?
A positive result means alpha-2 laminin was detected in the tissue. It does not by itself establish a specific diagnosis; the pathologist considers the staining pattern and clinical findings.
How long will the results take?
Timing varies with the laboratory and tissue-processing requirements. The ordering clinician or pathologist can provide an estimated turnaround time.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy