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Amino Acids, Cerebrospinal Fluid — Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

Measures the concentration of amino acids in cerebrospinal fluid to help evaluate certain metabolic and neurologic disorders.

Quick summary

["This specialized test measures amino acid levels in spinal fluid and requires interpretation alongside your symptoms and other test results."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
13366-0
Short code
AAA CSF-mCnc
Synonyms
AAA CSF-mCnc
Category
liver
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

What is this test?

This test measures the amount of different amino acids in cerebrospinal fluid, the fluid surrounding the brain and spinal cord. The results may help identify abnormalities in amino acid metabolism.

Why might I need this test?

It may be ordered when symptoms suggest an inherited metabolic disorder, a problem with neurotransmitter production, or another condition that affects the nervous system. It is generally a specialized test rather than part of routine cerebrospinal fluid analysis.

How is the test performed?

Cerebrospinal fluid is usually collected by lumbar puncture, also called a spinal tap. A laboratory then measures the amino acid concentrations in the collected fluid.

How do I prepare for the test?

There is usually no special preparation for the laboratory analysis, but a lumbar puncture has specific safety considerations. Follow your clinician's instructions and tell them about any blood thinners, bleeding disorders, back problems, or previous spinal procedures.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Abnormal amino acid concentrations may be associated with inherited metabolic conditions, nutritional problems, or changes in neurotransmitter metabolism. Results must be interpreted with age, symptoms, medications, and other cerebrospinal fluid findings because a single abnormal value is not enough to establish a diagnosis.

Short name

CSF amino acids

Frequently asked questions

Is this the same as an amino acid blood test?
No. This test measures amino acids in cerebrospinal fluid rather than in blood, and the results may not correspond directly to blood levels.
How is cerebrospinal fluid obtained?
It is most commonly collected through a lumbar puncture using a needle inserted into the lower back. A local anesthetic is often used to reduce discomfort.
Does an abnormal result mean I have a genetic disorder?
Not necessarily. Abnormal results can have several causes, so your clinician will consider the overall pattern and your clinical history before drawing conclusions.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy