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Alpha-1 Antitrypsin — Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of alpha-1 antitrypsin in a blood sample and is mainly used to evaluate low protein levels and inherited alpha-1 antitrypsin deficiency.

Quick summary

["Low alpha-1 antitrypsin levels may indicate an inherited deficiency that can affect the lungs and liver."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
16344-4
Short code
A-AIB Amn-mCnc
Synonyms
A-AIB Amn-mCnc
Category
liver
Sample
fluid
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
2-5 mL
Stability
Room temperature: 2h, Refrigerated: 24h
Hemolysis max
300
TAT
4–24 hours
Order
routine

What is this test?

Alpha-1 antitrypsin is a protein made by the liver that helps protect the lungs from inflammation. This test measures its concentration in a blood sample.

Why might I need this test?

Your clinician may order this test if you have unexplained liver disease, chronic lung disease, or a family history of alpha-1 antitrypsin deficiency. It may also be used to monitor a known deficiency.

How is the test performed?

A blood sample is collected and analyzed in the laboratory to determine the concentration of alpha-1 antitrypsin. The laboratory may use different testing methods, and the sample requirements are confirmed by the testing laboratory.

How do I prepare for the test?

This test usually requires no special preparation. Follow any instructions from your clinician, and tell the laboratory if you are pregnant, because pregnancy can increase alpha-1 antitrypsin levels.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Alpha-1 antitrypsin

Frequently asked questions

What does a low alpha-1 antitrypsin level mean?
It may indicate an inherited alpha-1 antitrypsin deficiency, although inflammation and other factors can also affect the result. Your clinician can interpret the result and recommend additional testing if needed.
Does this test require fasting?
Fasting is generally not required, but follow the instructions provided by your clinician or laboratory.
Can alpha-1 antitrypsin levels be high?
Yes. Levels can rise during inflammation, infection, pregnancy, and some other conditions. An elevated result does not necessarily indicate alpha-1 antitrypsin deficiency.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy