Skip to content

Alpha-1-Antitrypsin Phenotype, Plasma — Qualitative

Published: August 9, 2026Updated: August 16, 2026

A qualitative plasma test that identifies the pattern of the alpha-1 antitrypsin protein and helps evaluate inherited variants linked to alpha-1 antitrypsin deficiency.

Quick summary

["This test checks the form of alpha-1 antitrypsin in your blood, which can help identify an inherited deficiency risk."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
16341-0
Short code
A-AIB Plas Ql
Synonyms
A-AIB Plas Ql
Category
liver
Sample
plasma
Container
Lavender-top (EDTA) or Green-top (Heparin)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

This qualitative test evaluates the phenotype, or pattern, of the alpha-1 antitrypsin protein in plasma. It may identify protein variants associated with alpha-1 antitrypsin deficiency rather than measuring the exact protein concentration.

Why might I need this test?

A clinician may order this test when there is concern for alpha-1 antitrypsin deficiency, especially with unexplained liver disease, chronic lung disease, or a family history of the condition.

How is the test performed?

A blood sample is collected, and the laboratory separates the plasma for analysis. Laboratory methods may vary, so the laboratory's report should be reviewed for the specific result and any recommended follow-up.

How do I prepare for the test?

This test usually requires no special preparation. Follow any instructions provided by the laboratory or your clinician and tell them if you are pregnant or have received a blood or plasma transfusion recently.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Alpha-1 antitrypsin phenotype

Frequently asked questions

Does this test measure my alpha-1 antitrypsin level?
Not usually. A qualitative phenotype test identifies the pattern of the protein, while a separate alpha-1 antitrypsin concentration test measures how much is present.
Can a normal phenotype rule out alpha-1 antitrypsin deficiency?
A normal or usual phenotype generally makes common deficiency variants less likely, but interpretation depends on the specific method and clinical context. A clinician can advise whether additional testing is needed.
What conditions are associated with abnormal results?
Some alpha-1 antitrypsin variants are associated with liver disease, including cirrhosis, and with chronic lung disease such as emphysema. The meaning of a particular result varies with the variant identified and your medical history.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy