Understanding Your Laboratory Test: What to Expect and Why It Matters
This test measures the level of beta-guanidinopropionate, an amino acid derivative, in the cerebrospinal fluid to help evaluate neurological and metabolic conditions.
{"Measures beta-guanidinopropionate levels in cerebrospinal fluid","Helps evaluate neurological disorders related to creatine metabolism","Sample is collected via lumbar puncture (spinal tap)","Results help doctors diagnose rare metabolic brain diseases","Abnormal levels may indicate issues with brain energy metabolism"}
Key facts at a glance
- LOINC
- 13365-2
- Short code
- CSF Amino Beta Guanidino
- Synonyms
- AB-Gp CSF-mCnc
- Category
- chemistry
- Sample
- csf
- Container
- Sterile polypropylene container
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 0–120 years
- Method
- Liquid chromatography-tandem mass spectrometry (LC-MS/MS)
- CPT
- 82131
- SNOMED
- 25845001
- Specimen volume
- 0.5-1.0 mL CSF
- Stability
- CSF should be transported on ice and processed within 2-4 hours of collection. If analysis delayed, store at -70°C. Avoid repeated freeze-thaw cycles.
- Hemolysis max
- 200
- TAT
- 72–168 hours
- Order
- routine
This is a laboratory test that measures specific substances in your body to help your healthcare provider understand how well your organs are working and to detect signs of illness, infection, or other health conditions that may need further attention or treatment.
The Amino Beta Guanidinopropionate test measures the amount of beta-guanidinopropionate in your cerebrospinal fluid (CSF). Beta-guanidinopropionate is a derivative of the amino acid arginine and is related to creatine metabolism in the body. This test is part of specialized chemistry testing performed on CSF, which is the clear fluid that surrounds and protects your brain and spinal cord.
A sample, usually blood or urine, is collected by a trained healthcare professional in a clinic, hospital, or laboratory. The procedure is quick and generally causes little discomfort, and the sample is then sent to a laboratory for analysis by specialized staff.
The CSF sample is collected through a procedure called lumbar puncture, also known as a spinal tap. During this procedure, a healthcare provider inserts a thin needle between the bones in your lower spine to withdraw a small amount of cerebrospinal fluid. The area will be numbed to minimize discomfort. After the procedure, you may be asked to lie flat for a short time to reduce the risk of headache.
Your healthcare provider may order this test to help diagnose a medical condition, monitor an existing illness, check how well a treatment is working, or as part of a routine health evaluation to make sure your body is functioning normally.
This test is typically ordered by neurologists or metabolic specialists to help evaluate patients with suspected neurological disorders, particularly those related to abnormal creatine metabolism or energy production in the brain. It may be used when a patient shows symptoms such as developmental delays, movement disorders, seizures, or unexplained neurological problems.
Reference range
Reference range is laboratory-specific. Contact reference laboratory for interpretive values. Normal CSF concentrations of amino acids and derivatives are typically in the micromolar range.N/A
No special patient preparation required. Inform patient about lumbar puncture procedure and obtain informed consent. Ensure patient is adequately hydrated.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Frequently asked questions
Do I need to fast before this test?
How long does it take to get results?
Is the lumbar puncture painful?
What do abnormal results mean?
Are there any risks after the lumbar puncture?
Sources
- 1
- 2
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy