Complete Blood Count (CBC): What It Is, How It Is Done, and What Your Results Mean
This test checks for the presence of acetyl fentanyl, a synthetic opioid, in umbilical cord tissue to determine if a newborn was exposed to this substance during pregnancy.
{"Acetyl fentanyl is a powerful synthetic opioid that can cross the placenta","This test uses cord tissue to detect potential prenatal drug exposure","A positive result indicates the baby was exposed to opioids before birth","This information helps healthcare providers plan appropriate care for mother and baby","The test is performed using confirmatory laboratory methods for accuracy"}
Key facts at a glance
- LOINC
- 97215-8
- Short code
- ACF-CORD
- Synonyms
- Acetyl fentanyl TissCo Ql Cfm
- Category
- chemistry
- Sample
- serum
- Container
- Cord blood collection tube (EDTA or sodium fluoride) or cord tissue collection container
- Units
- N/A
- Critical range
- — – 0.5 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- ≥ 0 years
- Method
- confirm
- CPT
- 80307
- SNOMED
- 1224610009
- Specimen volume
- Minimum 2 mL cord blood or 5 grams cord tissue
- Stability
- Refrigerated (2-8°C): up to 7 days; Frozen (-20°C): up to 30 days; Frozen (-80°C): up to 90 days
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 48–72 hours
- Order
- routine
A complete blood count, commonly called a CBC, is one of the most frequently ordered blood tests. It measures the cells that make up your blood, including red blood cells, white blood cells, and platelets, and helps your healthcare provider assess your overall health and detect a wide range of conditions.
The acetyl fentanyl test is a laboratory analysis that detects the presence of acetyl fentanyl in umbilical cord tissue. Acetyl fentanyl is a synthetic opioid compound, similar to fentanyl but with slightly different chemical properties. It is classified as a Schedule I controlled substance in the United States due to its high potency and potential for abuse. This test is specifically designed to identify whether a developing fetus was exposed to this opioid during pregnancy.
For this test, a small sample of blood is drawn from a vein, usually on the inside of your elbow or the back of your hand. A healthcare professional will clean the site, wrap a band around your upper arm, insert a thin needle, and collect the blood into a tube. The process takes only a few minutes, and after the needle is removed, gentle pressure and a small bandage are applied.
After childbirth, a segment of the umbilical cord is collected by healthcare providers. The cord tissue is then sent to a laboratory for analysis. Cord tissue is particularly useful for this type of testing because it can reflect substances that circulated in the mother's blood and crossed the placenta during pregnancy. The confirmatory method used in this test provides highly reliable results.
This test is performed for many reasons, such as routine health checkups, evaluating symptoms like fatigue, weakness, fever, or unexplained bruising, monitoring an existing condition such as anemia or infection, and tracking how treatments like chemotherapy or certain medications are affecting your blood cells.
This test is primarily used in newborn screening and perinatal toxicology to identify infants who may have been exposed to opioids before birth. It helps healthcare providers identify babies who may need special care, monitoring, or treatment for neonatal abstinence syndrome (NAS), a condition that occurs when a newborn experiences withdrawal symptoms after being exposed to certain substances during pregnancy. Early detection allows for prompt intervention and appropriate management.
Your results show whether your blood cell counts fall within normal ranges. Abnormal values may point to conditions such as anemia, infection, inflammation, clotting problems, or bone marrow disorders. A single abnormal result does not confirm a diagnosis, so your provider will interpret the numbers together with your symptoms, medical history, and other tests before recommending any next steps.
A 'Positive' result means acetyl fentanyl was detected in the cord tissue, indicating that the mother used this substance during pregnancy and it crossed the placenta to reach the developing fetus. A 'Negative' result means no acetyl fentanyl was detected in the cord tissue at the time of birth. It's important to note that a negative result does not rule out exposure to other substances, and the mother may have used other drugs during pregnancy. The healthcare team will interpret results in conjunction with other clinical findings and tests.
Reference range
Not Detected - Cutoff: 0.5 ng/gN/A
No specific patient preparation required. Cord tissue sample collected at time of delivery. Inform laboratory of any maternal opioid medications or substance use.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
The detection of acetyl fentanyl in cord tissue is clinically significant because it indicates prenatal exposure to a potent opioid. Acetyl fentanyl is significantly more potent than morphine, and exposure during pregnancy can lead to neonatal complications including respiratory depression, sedation, and neonatal abstinence syndrome. This test helps healthcare providers identify at-risk newborns early so they can receive appropriate monitoring and treatment. It also assists in coordinating follow-up care, social services, and support for families affected by substance use disorders. The information obtained from this test is confidential and is used to provide medically necessary care rather than for punitive purposes.
Frequently asked questions
Is this test mandatory?
Will I be notified of the results?
What happens if the test is positive?
Can the test be wrong?
How long does it take to get results?
Sources
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Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy