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Alpha-1 Antitrypsin (Serum) Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of Alpha-1 Antitrypsin, a protein produced by the liver that helps protect the lungs and other organs from damage caused by enzymes released during inflammation.

Quick summary

["Alpha-1 Antitrypsin levels can help identify genetic conditions affecting lung or liver health."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
43625-3
Short code
AChR Ab Ser Ql
Synonyms
AChR Ab Ser Ql
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like chronic cough, shortness of breath, or liver issues, or if you have a family history of Alpha-1 Antitrypsin deficiency. It may also be used to monitor known conditions like emphysema or cirrhosis.

What to Expect Before the Test

No special preparation is needed for this blood test. You may have a small needle inserted into a vein in your arm to draw a blood sample. It usually takes a few minutes, and you can resume normal activities afterward.

What the Test Results Mean

Lower than expected levels of Alpha-1 Antitrypsin may indicate a genetic disorder called Alpha-1 Antitrypsin deficiency, which can lead to lung diseases or liver problems. Higher levels may be due to certain liver diseases or other conditions. Your healthcare provider will discuss the results with you in the context of your overall health.

Common Conditions Linked to Test Results

Alpha-1 Antitrypsin deficiency is linked to chronic obstructive pulmonary disease (COPD) and other lung diseases. It can also affect the liver. Regular monitoring may be recommended if you have a known deficiency or related symptoms.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Alpha-1 Antitrypsin (Serum)

Frequently asked questions

What does an abnormal Alpha-1 Antitrypsin level indicate?
Abnormally low levels may suggest Alpha-1 Antitrypsin deficiency, which can lead to lung diseases like emphysema or liver diseases like cirrhosis. Abnormally high levels might be associated with certain liver conditions or other health issues, but further evaluation is needed to understand the cause.
How often should I get this test if I have a known deficiency?
If you have been diagnosed with Alpha-1 Antitrypsin deficiency, your healthcare provider may recommend regular monitoring, often every few years, to track your condition and adjust treatment as needed. Follow their specific guidance based on your symptoms and health status.
Can lifestyle changes affect Alpha-1 Antitrypsin levels?
While lifestyle changes like quitting smoking can help manage symptoms related to lung disease, they do not directly alter the Alpha-1 Antitrypsin protein levels. However, maintaining a healthy lifestyle can support overall health and help manage related conditions better.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy