Skip to content

Acetylcholinesterase activity in serum/plasma (electrochemical method)

Published: August 9, 2026Updated: August 17, 2026

This test measures the level of acetylcholinesterase, an enzyme found in serum that helps break down the neurotransmitter acetylcholine. It may be checked to assess liver function or detect certain metabolic or neurological conditions.

Quick summary

["This test helps evaluate liver health and may support diagnosis of metabolic or neurological disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
5038-5
Short code
AChR Block Ab Titr Ser IF
Synonyms
AChR Block Ab Titr Ser IF
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
22
Ref high
198
Critical range
— – 10000 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
if
CPT
82553
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Doctors may order this test to investigate liver disease, such as hepatitis or cirrhosis, since acetylcholinesterase is produced in the liver. It can also be used in research or specialized clinical settings to monitor conditions affecting enzyme activity, though it is less commonly performed than other liver function tests.

What Does the Result Mean?

While reference ranges vary by lab, abnormal results may suggest liver dysfunction or other metabolic issues. Elevated levels could indicate liver disease, while very low levels might suggest enzyme deficiencies or certain metabolic disorders.

Common Reasons for Testing

This test is primarily used in research or specialized clinical contexts rather than routine patient care. It may be part of a broader evaluation for liver function or metabolic studies, but standard clinical practice often relies on more common liver function tests.

Sample Collection and Preparation

A blood sample is drawn from a vein, usually in the arm. The sample is processed to separate serum or plasma, which is then analyzed for acetylcholinesterase activity using an electrochemical method.

Reference range

Adult males: 22-198 U/L; Females: 22-198 U/LN/A

Specimen: serum

No special preparation required. Inform provider of any chest pain or symptoms.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Serum Acetylcholinesterase Activity

Frequently asked questions

What Are My Next Steps If My Result Is Abnormal?
If your acetylcholinesterase result is outside expected ranges, your healthcare provider will discuss the findings with you. They may recommend additional tests, such as liver function tests (e.g., ALT, AST, bilirubin), or further evaluation depending on the context of your care.
Could This Test Be Related to My Medications?
Some medications or conditions may indirectly affect enzyme levels, but acetylcholinesterase is primarily liver-produced. If you’re on medications, discuss potential interactions with your doctor.
How Often Should I Get This Test?
This test is not routinely recommended for most patients. It may be ordered only in specific clinical scenarios, such as research studies or specialized diagnostic evaluations.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy