11-Dehydrocorticosterone (Acortolone), 24-Hour Urine — Substance Concentration
Measures 11-dehydrocorticosterone (acortolone), an adrenal steroid metabolite, in urine collected for 24 hours to help evaluate adrenal hormone production.
["This specialized urine test can help identify abnormal adrenal steroid production, including some forms of congenital adrenal hyperplasia."]
Key facts at a glance
- LOINC
- 73872-4
- Short code
- A-cortolone 24h Ur-sCnc
- Synonyms
- A-cortolone 24h Ur-sCnc
- Category
- liver
- Sample
- urine
- Container
- Sterile urine container
- Units
- N/A
- Ref low
- 20
- Ref high
- 400
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 82670
- Specimen volume
- 10 mL
- Stability
- Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
What is this test?
This test measures 11-dehydrocorticosterone, also called acortolone, in a 24-hour urine collection. It is a substance related to adrenal steroid and cortisol production.
Why might I need this test?
A clinician may order this test to evaluate unusual adrenal hormone production. It can be useful when investigating suspected 11β-hydroxylase deficiency, a form of congenital adrenal hyperplasia, or other complex adrenal conditions.
How is the test performed?
You collect all urine for exactly 24 hours, usually in a labeled container provided by the laboratory. The urine should be refrigerated during collection and brought to the lab as directed; the total amount collected is recorded.
How do I prepare for the test?
Follow the laboratory's collection instructions carefully, including the starting time, storage, and any medication restrictions. Do not change medications or fluid intake unless your clinician specifically instructs you to do so.
Reference range
Premenopausal: 20-400 pg/mL; Postmenopausal: <30 pg/mLN/A
No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Elevated urinary 11-dehydrocorticosterone may indicate altered adrenal steroid production, particularly 11β-hydroxylase deficiency. Subnormal results are less specific and can be influenced by an incomplete collection or reduced adrenal steroid production. Results should be interpreted with symptoms, medication use, and other adrenal hormone tests.
Short name
24-Hour Urine 11-Dehydrocorticosterone
Frequently asked questions
What is acortolone?
Why is urine collected for 24 hours?
Do I need to fast for this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy