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Cortolone and Related Cortisol Precursor Metabolites, 24-Hour Urine — Mass Rate

Published: August 9, 2026Updated: August 16, 2026

A 24-hour urine test measuring cortolone and related adrenal steroid metabolites to help evaluate cortisol production and adrenal steroid disorders.

Quick summary

["This test measures daily urinary levels of cortolone and related cortisol precursor metabolites."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
57634-8
Short code
A-cortolone Pre Dex 24h Ur-mRate
Synonyms
A-cortolone Pre Dex 24h Ur-mRate
Category
liver
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What is this test?

This test measures cortolone and related cortisol precursor metabolites in urine collected over 24 hours. The results show the amount excreted each day and can help evaluate adrenal steroid production.

Why might I need this test?

A clinician may order this test when symptoms or laboratory findings suggest an adrenal steroid disorder. It may be used in the evaluation of congenital adrenal hyperplasia, abnormal cortisol production, or unexplained hormonal symptoms.

How is the test performed?

Urine is collected into a designated container for a full 24-hour period. The laboratory then measures the amount of cortolone and related precursor metabolites, often reported as mass per day.

How do I prepare for the test?

Follow the collection instructions provided by the laboratory and collect all urine for the full 24 hours. Tell your clinician about corticosteroid or other hormone medicines, because they may affect the results.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

24-Hour Urine Cortolone and Precursor Metabolites

Frequently asked questions

Why is a 24-hour urine collection needed?
A timed collection measures the total amount excreted each day rather than the concentration at one moment. This can provide a more representative measure of adrenal steroid metabolite production.
Can medicines affect the results?
Yes. Corticosteroids and some other hormone medicines can change adrenal steroid production and metabolite levels. Do not stop medicines on your own; discuss them with your clinician before the test.
What if part of the urine collection is missed?
A missed or incomplete collection may make the daily amount falsely low or otherwise unreliable. Contact the laboratory for instructions if the collection was not complete.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy