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LDL Cholesterol, Serum/Plasma — Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

This blood test measures low-density lipoprotein (LDL) cholesterol, a substance that can contribute to fatty buildup in arteries.

Quick summary

["LDL cholesterol helps assess cardiovascular risk, but results are best interpreted with your other cholesterol levels and health history."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
43395-3
Short code
Ac-VLDLc SerPl-mCnc
Synonyms
Ac-VLDLc SerPl-mCnc
Category
lipid
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0
Ref high
100
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
83721
SNOMED
113079007
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

This test measures the amount of LDL, or “bad,” cholesterol in a blood sample. LDL helps transport cholesterol through the bloodstream and can contribute to plaque buildup in arteries.

Why might I need this test?

Your clinician may order this test to help assess your risk of heart disease and stroke, monitor cholesterol treatment, or evaluate a broader cholesterol panel.

How is the test performed?

A blood sample is drawn and analyzed in a laboratory. Depending on the laboratory, LDL cholesterol may be calculated from other cholesterol measurements or measured directly.

How do I prepare for the test?

Fasting may not be required for every LDL cholesterol test, but your clinician may request it when testing is part of a complete lipid panel. Follow the instructions provided with your lab order.

Reference range

Optimal: <100 mg/dLN/A

Specimen: serum

Fasting for 12-14 hours preferred. Water is permitted. Avoid alcohol for 24 hours before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

An elevated LDL cholesterol level can increase the risk of atherosclerosis, heart disease, and stroke. Your clinician will interpret the result based on your overall cardiovascular risk, medications, family history, and other cholesterol measurements.

Short name

LDL cholesterol

Frequently asked questions

Is LDL cholesterol the same as “bad” cholesterol?
Yes. LDL is often called “bad” cholesterol because it can contribute to cholesterol buildup in artery walls.
Do I need to fast before this test?
Not always. Fasting requirements vary, so follow your clinician’s or laboratory’s instructions, especially if other tests are being done at the same time.
Can diet and medication change my LDL cholesterol?
Yes. Heart-healthy eating, exercise, weight management, and prescribed cholesterol-lowering medicines can affect LDL levels. Do not change medication without speaking with your clinician.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy