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Adeninecsfscnc

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of adenine, a building block of DNA and RNA, in the fluid surrounding the brain and spinal cord.

Quick summary

{"Adenine is a natural chemical found in all body cells","This test helps doctors study brain and nervous system metabolism","It may aid in diagnosing certain neurological or metabolic conditions","The test requires a lumbar puncture (spinal tap) to collect fluid","Results help researchers understand how brain cells produce energy"}

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
75133-9
Short code
CSF-ADEN
Synonyms
Adenine CSF-sCnc
Category
chemistry
Sample
csf
Container
Sterile CSF collection tube (plain red-top or sterile container). Avoid contamination. Transport to laboratory immediately.
Units
N/A
Ref low
0.1
Ref high
0.5
Fasting
false
Population
adult
Sex
all
Age range
≥ 0 years
Method
High Performance Liquid Chromatography (HPLC) with UV detection or Mass Spectrometry
CPT
80378
SNOMED
122575004
Specimen volume
1-2 mL of CSF is typically sufficient for analysis
Stability
CSF should be processed within 2-4 hours of collection. If delay expected, store at 2-8°C and analyze within 24-48 hours. Protect from light.
Hemolysis max
200
TAT
48–96 hours
Order
routine

What is this test?

The Cerebrospinal Fluid (CSF) Adenine test measures how much adenine is present in the fluid that surrounds your brain and spinal cord. Adenine is one of the four building blocks of DNA and RNA, which carry genetic information in all cells. This test is a specialized chemistry test that helps doctors understand how brain cells are functioning and metabolizing (producing energy).

Why is it done?

Healthcare providers may order this test to study neurological conditions, investigate metabolic disorders that affect the nervous system, or understand brain chemistry. It is particularly useful in research settings and complex diagnostic cases where standard tests do not provide enough information. The test helps evaluate purine metabolism—the process by which the body breaks down and uses adenine and related chemicals.

How is the sample collected?

A healthcare provider collects cerebrospinal fluid through a procedure called a lumbar puncture, commonly known as a spinal tap. The patient usually lies on their side while a thin needle is inserted between two vertebrae in the lower spine to withdraw a small amount of fluid. The procedure takes about 15-30 minutes. After collection, the fluid is sent to a laboratory for analysis.

Reference range

Reference range not well established. Laboratory-specific reference ranges should be validated. Typical reported range: 0.1-0.5 micromol/L (0.1-0.5 umol/L). Clinical interpretation should correlate with patient's clinical presentation and underlying neurological condition.N/A

Specimen: csf

No special patient preparation required. Inform patient about lumbar puncture procedure. Ensure informed consent is obtained. Advise patient to remain still during collection.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Frequently asked questions

Is this test painful?
The lumbar puncture procedure may cause some discomfort or a brief stinging sensation. Your healthcare provider will use a local anesthetic to minimize pain. Some patients may experience a mild headache afterward, which usually resolves with rest and hydration.
How long does it take to get results?
Results typically take several days to a week, as this is a specialized test that requires specific laboratory equipment and expertise. The laboratory will send results to your healthcare provider, who will discuss them with you.
Do I need to fast before this test?
Fasting is generally not required for this test. However, always follow your healthcare provider's specific instructions regarding preparation.
What do high adenine levels mean?
Elevated adenine levels in CSF may be associated with certain metabolic disorders, neurological conditions, or brain injury. Your healthcare provider will interpret your results in the context of your overall health, symptoms, and other test findings.
  1. 1
    MedlinePlus - Lumbar Puncture (Spinal Tap)Source
  2. 2
    LOINC Code 75133-9 ReferenceSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy