Understanding Your Diagnostic Test: A Patient Guide
A specialized blood test that measures adenine levels in serum to evaluate nucleobase metabolism and certain metabolic conditions.
{"Adenine is a fundamental building block of DNA and RNA","This test helps diagnose rare metabolic disorders affecting nucleobase breakdown","Sample is collected through a standard blood draw","Results are interpreted by healthcare providers in context of symptoms","Abnormal results may indicate genetic metabolic conditions"}
Key facts at a glance
- LOINC
- 4108-7
- Short code
- ADEN
- Synonyms
- Adenine Dose
- Category
- chemistry
- Sample
- serum
- Container
- 24-hour urine collection container (dark amber or plastic container with preservatives as required by laboratory)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- ≥ 18 years
- Method
- Liquid chromatography-tandem mass spectrometry (LC-MS/MS) or High-performance liquid chromatography (HPLC)
- CPT
- 82175 ( Adenine, urine, quantitative )
- SNOMED
- 314235006
- Specimen volume
- Complete 24-hour collection; typical volume 1000-2000 mL depending on urine output
- Stability
- Refrigerate at 2-8°C during collection. Store at -20°C or below if analysis delayed beyond 24 hours. Protect from light if applicable.
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 72–168 hours
- Order
- routine
This test is a medical evaluation that helps your healthcare provider gather important information about your health. The results can be used to diagnose a condition, monitor an ongoing problem, or guide decisions about your treatment and follow-up care.
The Adenine test measures the amount of adenine, a nucleobase, in your blood serum. Adenine is one of the four main nucleobases that make up DNA and RNA (along with guanine, cytosine, and thymine/uracil). While adenine is naturally produced by your body and is essential for genetic material, abnormal levels may indicate certain metabolic disorders.
Your provider may recommend this test if you have symptoms that need clarification, risk factors for certain conditions, a family history of disease, or an existing health condition that requires regular monitoring to make sure your treatment plan is working as expected.
Your healthcare provider may order this test if they suspect a rare metabolic disorder affecting how your body processes purines (the category of molecules that adenine belongs to). This may include conditions like adenine phosphoribosyltransferase deficiency or other purine metabolism disorders. Symptoms that might prompt testing include kidney stones, recurrent urinary tract infections, or unusual neurological symptoms.
The test is usually performed in a clinic, hospital, or laboratory setting by a trained healthcare professional. Depending on the type of test, it may involve providing a small sample or having a simple examination. The procedure is generally quick, and most patients tolerate it well.
A healthcare professional will draw a small sample of blood from a vein in your arm. The blood is collected in a special tube, allowed to clot, and then the serum (the liquid part of blood) is separated for analysis. The procedure is quick and similar to routine blood tests.
Reference range
Reference range not well established; varies by laboratory methodology and population. Clinical interpretation based on specific clinical context and comparison to baseline values.N/A
No specific fasting required. Maintain usual fluid intake unless otherwise instructed. Avoid dietary supplements containing adenine or purine-rich foods 24 hours prior to collection if possible.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Frequently asked questions
Do I need to fast before this test?
Are there any risks with this blood test?
How long does it take to get results?
What do abnormal results mean?
Sources
- 1
- 2
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy