Skip to content

Alpha-Fetoprotein, Serum/Plasma — Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

Measures AFP in blood to help evaluate liver disease and monitor certain liver or germ-cell tumors. Results are interpreted with other findings.

Quick summary

["An AFP blood test can provide useful information, but an abnormal result alone does not confirm a specific condition."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
109613-0
Short code
AFP Msmt Plr
Synonyms
AFP Msmt Plr
Category
liver
Sample
fluid
Container
Sterile tube
Units
N/A
Ref low
0
Ref high
10
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82105
SNOMED
394971007
Specimen volume
2-5 mL
Stability
Room temperature: 2h, Refrigerated: 24h
Hemolysis max
300
TAT
4–24 hours
Order
routine

What is this test?

This blood test measures alpha-fetoprotein (AFP), a protein made by the developing liver and certain other tissues. The amount in blood can change with liver conditions, some tumors, and pregnancy.

Why might I need this test?

AFP may be used to help evaluate liver disease and to monitor people with liver cancer or certain germ-cell tumors. It may also be included as part of specialized prenatal screening, depending on the reason for testing.

How is the test performed?

A blood sample is drawn and sent to a laboratory, where the laboratory measures the amount of AFP. No special imaging or procedure is needed for the blood test itself.

How do I prepare for the test?

Fasting is usually not required for an AFP test, but follow any instructions from your healthcare professional. Tell the laboratory if you are pregnant because pregnancy can affect the result.

Reference range

Normal: <10 ng/mLN/A

Specimen: fluid

No special preparation required. For PSA, avoid sexual activity for 24-48 hours before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Alpha-fetoprotein (AFP)

Frequently asked questions

Does an abnormal AFP result mean I have cancer?
No. Elevated AFP can have several causes, including pregnancy and noncancerous liver disease, and it is not specific for cancer. Your clinician will interpret it alongside other findings.
Is fasting required for an AFP blood test?
Fasting is generally not required. If your clinician gave specific preparation instructions, follow those instructions.
Why might my AFP level change during follow-up?
AFP can rise or fall as liver inflammation, tumor activity, pregnancy, or treatment status changes. Serial results are often more useful than a single measurement.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy