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Albumincsfscnc

Published: July 31, 2026Updated: August 17, 2026

This test measures the amount of albumin protein in the cerebrospinal fluid (CSF), the clear liquid surrounding the brain and spinal cord.

Quick summary

{"A CSF albumin test checks for proteins in the fluid around your brain and spine","It helps doctors evaluate the blood-brain barrier integrity","Sample is collected through a lumbar puncture (spinal tap)","Abnormal results may indicate infections, bleeding, or neurological diseases","The test is performed in a clinical laboratory by trained specialists"}

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
76480-3
Short code
CSFALB
Synonyms
Albumin CSF-sCnc
Category
chemistry
Sample
csf
Container
Sterile CSF collection tube (plain polypropylene tube)
Units
not specified
Ref low
10
Ref high
35
Critical range
1.5 not specified – —
Fasting
false
Population
adult
Sex
all
Age range
0–120 years
Method
Immunonephelometry or immunoturbidimetry
CPT
82040
SNOMED
271588005
Specimen volume
0.5-1.0 mL CSF minimum
Stability
Analyze within 2-4 hours of collection; if delay, refrigerate at 2-8°C for up to 24 hours; avoid repeated freezing/thawing
Hemolysis max
50
Lipemia max
100
Icterus max
20
TAT
1–24 hours
Order
routine

What is this test?

The CSF Albumin test measures the concentration of albumin, a protein produced by the liver, in the cerebrospinal fluid. Cerebrospinal fluid is a clear, protective liquid that cushions the brain and spinal cord. This test helps doctors understand how well the blood-brain barrier is functioning and whether there are any abnormalities in the central nervous system.

How is the sample collected?

The sample is collected through a procedure called a lumbar puncture, also known as a spinal tap. During this procedure, a healthcare provider inserts a thin needle into the lower back to withdraw a small amount of cerebrospinal fluid. The area is first numbed with a local anesthetic to minimize discomfort. The procedure typically takes about 15-30 minutes, and patients may be asked to lie flat for a short time afterward to reduce the risk of headache.

Why is albumin measured in CSF?

Albumin is normally found in blood but not in high amounts in CSF. When the blood-brain barrier is healthy, it prevents albumin from entering the cerebrospinal fluid. Measuring CSF albumin helps doctors determine if the blood-brain barrier has been compromised. This can be important for diagnosing various neurological conditions, monitoring disease progression, or evaluating treatment effectiveness.

What should I expect during the test?

Before the test, inform your doctor about any medications you're taking, especially blood thinners. During the lumbar puncture, you'll likely lie on your side with knees drawn up to your chest, or sit leaning forward. The healthcare provider will clean the lower back area, apply numbing medicine, and insert the needle to collect fluid. You may feel pressure or a brief sting. Afterward, rest as recommended and drink plenty of fluids.

Reference range

10-35 mg/dLnot specified

Specimen: csf

No special preparation or fasting required; specimen obtained by lumbar puncture

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Frequently asked questions

Is the lumbar puncture procedure painful?
A local anesthetic is used to numb the area, so you may feel a brief sting or burning sensation during the injection. During the needle insertion, you may feel pressure or discomfort, but it is usually tolerable. Some people may experience a headache afterward, which can be managed with rest and fluids.
How long does it take to get results?
Results are typically available within a few days to a week, depending on the laboratory. Your healthcare provider will contact you with the results or discuss them at a follow-up appointment.
Are there any risks associated with this test?
The most common side effect is a headache, which occurs in about 10-30% of patients. Other rare risks include bleeding, infection, or nerve irritation at the puncture site. Serious complications are very uncommon when the procedure is performed by experienced healthcare professionals.
Do I need to fast before the test?
No fasting is typically required for this test. However, follow any specific instructions provided by your healthcare provider. Make sure to inform them of all medications and supplements you are taking.
What do high albumin levels mean?
High CSF albumin levels suggest that the blood-brain barrier may be damaged or permeable. This can happen due to various conditions including infections (meningitis, encephalitis), inflammatory diseases (multiple sclerosis), bleeding in the brain or spinal cord, tumors, or after certain medical procedures. Your doctor will interpret the results in context of your symptoms and other test findings.
  1. 1
    MedlinePlus - Lumbar PunctureSource
  2. 2
    Mayo Clinic Laboratories - CSF AlbuminSource
  3. 3
    Lab Tests Online - CSF AnalysisSource

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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy