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Alkaline Phosphatase Activity in Serum/Plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of alkaline phosphatase, an enzyme found in your blood that helps break down certain compounds. It can help assess bone health, liver function, and other metabolic processes.

Quick summary

["ALP helps identify issues in bone formation, liver disease, or other conditions affecting enzyme activity."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
73540-7
Short code
Alendronate ind plt IgM SerPl Ql FC
Synonyms
Alendronate ind plt IgM SerPl Ql FC
Category
hematology
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
flow-cytometry
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why It’s Done

Your healthcare provider may order this test if you have symptoms like bone pain, liver problems (such as jaundice or fatigue), or if you’re at risk for conditions like osteoporosis, liver disease, or certain cancers. It can also be part of routine check-ups for children growing rapidly or adults with known bone or liver issues.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the test if it’s part of a liver function panel. Tell your provider about any medications, supplements, or recent illnesses, as they can affect results.

What the Results Mean

Elevated levels may suggest bone disorders, liver disease, or other metabolic conditions. Lower-than-normal levels could indicate bone demineralization or certain genetic disorders. Results are interpreted in the context of your overall health and symptoms.

Common Conditions Affecting Results

Conditions like liver disease, bone fractures, or hyperthyroidism can raise ALP levels. Low levels may occur with conditions like rickets, hypophosphatasia, or severe malnutrition. Always discuss results with your provider.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Alkaline Phosphatase (ALP)

Frequently asked questions

How often do I need this test?
Your provider will determine frequency based on your health status. Children may get it more often during growth spurts, while adults may need it periodically if they have ongoing bone or liver concerns.
Can diet or medications affect ALP levels?
Yes—certain foods (like fatty foods or vitamin D supplements) or medications (e.g., anticonvulsants, steroids) can temporarily change results. Always inform your provider about everything you take.
What if my results are out of the normal range?
Your provider will explain what the results mean in relation to your health. They may recommend further testing or adjustments to treatment if needed.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy