Alpha-1 Globulin, Electrophoresis, Mass Fraction
Alpha-1 globulin fraction is measured by protein electrophoresis to assess the relative amount of this protein group and help evaluate liver, inflammation, or protein-loss patterns.
["This test reports the proportion of alpha-1 globulins in a blood sample and is interpreted alongside the rest of the protein profile."]
Key facts at a glance
- LOINC
- 15125-8
- Short code
- Alpha1 Glob MFr Snv Elph
- Synonyms
- Alpha1 Glob MFr Snv Elph
- Category
- liver
- Sample
- fluid
- Container
- Sterile tube
- Units
- N/A
- Ref low
- 44
- Ref high
- 147
- Critical range
- 7.2 N/A – 7.6 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- electrophoresis
- CPT
- 84075
- SNOMED
- 27550007
- Specimen volume
- 2-5 mL
- Stability
- Room temperature: 2h, Refrigerated: 24h
- Hemolysis max
- 300
- TAT
- 4–24 hours
- Order
- routine
What is this test?
Alpha-1 globulins are a group of proteins that separate into a distinct region during protein electrophoresis. This test reports their mass fraction, meaning their relative proportion compared with the other protein groups measured.
Why might I need this test?
This result is usually part of a serum or plasma protein electrophoresis panel. It may help evaluate changes associated with inflammation, liver disease, impaired protein production, nutritional problems, or loss of protein through the kidneys.
How is the test performed?
A blood sample is separated by protein electrophoresis. The laboratory then measures the alpha-1 globulin region and calculates its proportion of the total protein pattern.
How do I prepare for the test?
No special preparation is usually needed. Follow your healthcare professional's instructions and tell the laboratory if you are pregnant or have received a blood transfusion, because these can affect protein electrophoresis results.
Reference range
Adult: 44-147 U/LN/A
No special preparation required. Avoid fatty meals before the test if possible.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
An increased alpha-1 globulin fraction may occur with inflammation, infection, or certain other acute-phase conditions. A decreased fraction may be associated with impaired liver protein production, poor nutritional status, or loss of protein in urine. The result should be interpreted with the other electrophoresis fractions, total protein, and your medical history; it is not the same as a direct alpha-1 antitrypsin test.
Short name
Alpha-1 globulin fraction
Frequently asked questions
Is alpha-1 globulin the same as alpha-1 antitrypsin?
Does an abnormal result diagnose a specific condition?
Are reference ranges provided with this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy