Alpha-1 Globulin, Serum/Plasma — Mass Concentration
Measures the amount of alpha-1 globulin, a group of blood proteins that includes alpha-1 antitrypsin, in serum or plasma.
["This test measures alpha-1 globulin in the blood and may help evaluate liver disease, inflammation, or possible alpha-1 antitrypsin deficiency."]
Key facts at a glance
- LOINC
- 104786-9
- Short code
- Alpha1 Glob SerPl-mCnc
- Synonyms
- Alpha1 Glob SerPl-mCnc
- Category
- liver
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 44
- Ref high
- 147
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 84075
- SNOMED
- 27550007
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What is this test?
Alpha-1 globulin is a group of proteins found in the blood. This test measures the amount of this protein group in serum or plasma. Alpha-1 antitrypsin is an important component of the group.
Why might I need this test?
Your doctor may order this test as part of a broader evaluation of liver function, inflammation, or an abnormality found on protein testing. It may also be used alongside a specific alpha-1 antitrypsin test when a deficiency is suspected.
How is the test performed?
A blood sample is drawn, and the liquid portion is separated into serum or plasma. A laboratory then measures the amount of alpha-1 globulin using a validated protein-testing method.
How do I prepare for the test?
No special preparation is usually required. Follow your doctor's instructions and tell the laboratory if you are pregnant, recently ill, or taking medicines that could affect liver or protein levels. Fasting is generally unnecessary unless specifically requested.
Reference range
Adult: 44-147 U/LN/A
No special preparation required. Avoid fatty meals before the test if possible.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
A low alpha-1 globulin level may occur with alpha-1 antitrypsin deficiency, some forms of liver disease, or conditions that affect protein production. A high level may occur during inflammation or with some liver disorders. Results should be interpreted with your medical history and other laboratory tests.
Short name
Alpha-1 globulin
Frequently asked questions
Is alpha-1 globulin the same as alpha-1 antitrypsin?
Does a low result confirm alpha-1 antitrypsin deficiency?
Do I need to fast before this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy