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Alpha-2 Globulin, Cerebrospinal Fluid — Electrophoresis, Mass Fraction

Published: August 9, 2026Updated: August 16, 2026

Measures the relative amount of alpha-2 globulin in cerebrospinal fluid using electrophoresis to help evaluate cerebrospinal fluid protein patterns.

Quick summary

["This test measures the alpha-2 globulin fraction of protein in cerebrospinal fluid and is interpreted alongside the other protein fractions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
13975-8
Short code
Alpha2 Glob MFr CSF Elph
Synonyms
Alpha2 Glob MFr CSF Elph
Category
liver
Sample
csf
Container
Sterile tube
Units
N/A
Ref low
44
Ref high
147
Critical range
7.2 N/A – 7.6 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
electrophoresis
CPT
84075
SNOMED
27550007
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

What is this test?

This test measures the mass fraction of alpha-2 globulin, a group of proteins, in cerebrospinal fluid (CSF). It is usually reported as part of CSF protein electrophoresis.

Why might I need this test?

A clinician may order it when evaluating suspected inflammation, infection, or another condition affecting the brain or spinal cord. The result can help characterize the overall CSF protein pattern.

How is the test performed?

Cerebrospinal fluid is collected through a lumbar puncture, also called a spinal tap. The laboratory separates the CSF proteins using electrophoresis and estimates the proportion represented by the alpha-2 globulin fraction.

How do I prepare for the test?

No special food or fasting preparation is usually required. Follow the clinician's instructions for the lumbar puncture, including how long to remain lying down afterward, and do not stop any medication without medical advice.

Reference range

Adult: 44-147 U/LN/A

Specimen: csf

No special preparation required. Avoid fatty meals before the test if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

CSF Alpha-2 Globulin Fraction

Frequently asked questions

Is a lumbar puncture painful?
A lumbar puncture can cause brief pressure or discomfort, but local anesthetic is usually used to reduce pain. Most people do not have significant pain during the procedure.
Are there risks from a lumbar puncture?
Common effects include headache, back discomfort, or nausea. Rare complications can include bleeding, infection, or nerve irritation, and the clinical team should review your medical history before the procedure.
Can this test diagnose a specific condition?
No. The alpha-2 globulin fraction is one part of a broader CSF evaluation and must be interpreted by a clinician using the overall protein pattern and other findings.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy