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Alpha-2 Globulin, Serum/Plasma — Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

Measures the alpha-2 globulin protein fraction in blood, which can help evaluate inflammation, liver function, protein loss, and red blood cell breakdown.

Quick summary

["Abnormal alpha-2 globulin levels may reflect inflammation or changes involving the liver, protein loss, or red blood cell breakdown."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
104799-2
Short code
Alpha2 Glob SerPl-mCnc
Synonyms
Alpha2 Glob SerPl-mCnc
Category
liver
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
44
Ref high
147
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
84075
SNOMED
27550007
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

This blood test measures the amount of alpha-2 globulin, a fraction of blood proteins that includes substances involved in inflammation and red blood cell protection. It is often interpreted as part of a broader evaluation of the blood protein profile.

Why might I need this test?

A clinician may order this test when evaluating unexplained inflammation, liver disease, protein loss through the kidneys, or possible hemolysis, which is the breakdown of red blood cells. Results may also help interpret the pattern of other blood protein fractions.

How is the test performed?

A blood sample is collected and analyzed in the laboratory to determine the concentration of alpha-2 globulin in serum or plasma. The result is usually reported as a mass concentration, meaning the amount of this protein fraction per unit volume of blood.

How do I prepare for the test?

No special preparation is usually required for a single blood draw. Follow any instructions provided by your clinician, particularly if this test is being ordered alongside other tests that may require fasting.

Reference range

Adult: 44-147 U/LN/A

Specimen: serum

No special preparation required. Avoid fatty meals before the test if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Alpha-2 globulin

Frequently asked questions

What does alpha-2 globulin measure?
It measures a group of blood proteins found in the alpha-2 region of protein separation. This fraction includes proteins that respond to inflammation and help protect red blood cells.
What can cause a high alpha-2 globulin result?
A high result commonly reflects an active inflammatory process. Other causes, such as reduced protein clearance, may also contribute, so the result is interpreted with other tests.
What can cause a low alpha-2 globulin result?
Low levels may occur with liver disease, loss of protein through the kidneys, or increased red blood cell breakdown. Your clinician will consider your medical history and other laboratory results when interpreting the value.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy