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Alpha-Amino Acids, Cerebrospinal Fluid — Substance Concentration

Published: August 9, 2026Updated: August 16, 2026

A specialized test that measures amino acids in cerebrospinal fluid to help evaluate suspected inborn errors of amino acid metabolism.

Quick summary

["This test can help identify certain inherited metabolic disorders when symptoms suggest an amino acid problem."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
79280-4
Short code
Alpha-AASA CSF-sCnc
Synonyms
Alpha-AASA CSF-sCnc
Category
liver
Sample
csf
Container
Sterile tube
Units
N/A
Ref low
44
Ref high
147
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
84075
SNOMED
27550007
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

What is this test?

Cerebrospinal fluid amino acid testing measures the concentration of amino acids in the fluid surrounding the brain and spinal cord. It is a specialized laboratory test used in selected patients with developmental, neurologic, or metabolic symptoms.

Why might I need this test?

Your clinician may order this test when symptoms suggest an inherited disorder of amino acid metabolism. It may also be used as part of an evaluation for unusual developmental or neurologic findings.

How is the test performed?

A small sample of cerebrospinal fluid is usually collected through a lumbar puncture. The laboratory then measures and evaluates the amino acids in the sample using validated biochemical testing methods.

How do I prepare for the test?

Fasting is not required unless your clinician specifically requests it, because eating can affect amino acid levels. Follow all collection-time and medication instructions, and tell the care team about recent illness, diet changes, and medicines or supplements you use.

Reference range

Adult: 44-147 U/LN/A

Specimen: csf

No special preparation required. Avoid fatty meals before the test if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

CSF amino acids

Frequently asked questions

Is this the same as a blood amino acid test?
No. This test measures amino acids in cerebrospinal fluid rather than blood. Blood amino acid testing is a different and more commonly performed test.
Does the test require a lumbar puncture?
Yes, cerebrospinal fluid is generally obtained through a lumbar puncture. Your clinician will explain the procedure, its risks, and how the sample will be collected.
Can I interpret the result without reference ranges?
No. The laboratory or your clinician should interpret the pattern in the context of age, symptoms, medications, diet, and the laboratory's reference information.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy