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Alpha-Internexin IgG, Cerebrospinal Fluid — Qualitative, Immunoassay

Published: August 9, 2026Updated: August 16, 2026

A qualitative CSF test that detects IgG associated with alpha-internexin, a nervous-system protein.

Quick summary

["This test checks whether alpha-internexin IgG is present in cerebrospinal fluid."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
96482-5
Short code
Alpha-internexin IgG CSF Ql CBA IFA
Synonyms
Alpha-internexin IgG CSF Ql CBA IFA
Category
liver
Sample
csf
Container
Sterile tube
Units
N/A
Ref low
44
Ref high
147
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
cba-ifa
CPT
84075
SNOMED
27550007
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

What is this test?

This is a qualitative laboratory test of cerebrospinal fluid, or CSF. It uses an immunoassay to detect IgG associated with alpha-internexin, a protein found in nervous-system cells.

Why might I need this test?

This test may be considered in selected evaluations of neurologic symptoms when a clinician suspects an immune-related condition. It is not a general screening test and is usually interpreted along with symptoms, examination findings, and other laboratory results.

How is the test performed?

A small sample of CSF is collected through a lumbar puncture, also called a spinal tap. The laboratory then uses an immunoassay to determine whether alpha-internexin IgG can be detected.

How do I prepare for the test?

There are usually no special preparation instructions beyond following your clinician's directions. Because lumbar puncture involves a needle, tell the healthcare team about any bleeding problems, blood-thinning medicines, back problems, or previous reactions to local anesthetic.

Reference range

Adult: 44-147 U/LN/A

Specimen: csf

No special preparation required. Avoid fatty meals before the test if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

A positive result means alpha-internexin IgG was detected in the CSF. In the appropriate clinical context, this may support an immune-mediated neurologic process, but it is not diagnostic by itself and can have different significance depending on the assay and condition being evaluated. A negative result does not completely exclude the condition because testing sensitivity is limited.

Short name

CSF Alpha-Internexin IgG

Frequently asked questions

Is this the same as a routine blood test?
No. This test is performed on cerebrospinal fluid rather than blood, so a blood test cannot be assumed to provide the same result.
What does a positive result mean?
It means alpha-internexin IgG was detected in the CSF. This may be relevant in certain neurologic evaluations, but the finding must be interpreted with your symptoms and other test results.
Does a negative result rule out a neurologic condition?
No. A negative result means the test did not detect alpha-internexin IgG, but some affected people may still have a negative result. Your clinician will interpret it using the overall clinical picture.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy