Alpliver2cfrserpl
A blood test that measures the liver-specific portion of alkaline phosphatase enzyme to evaluate liver function and detect liver or bone disorders.
{"Measures the liver-derived alkaline phosphatase enzyme in your blood","Helps diagnose liver diseases like hepatitis, cirrhosis, or bile duct obstruction","Elevated levels may also indicate bone disorders such as Paget's disease","Results are compared with total ALP to determine if the increase is liver-related","Simple blood draw test, usually done as part of routine liver function testing"}
Key facts at a glance
- LOINC
- 15349-4
- Short code
- ALP isoenzyme ratio
- Synonyms
- ALP Liver 2 CFr SerPl
- Category
- chemistry
- Sample
- serum
- Container
- Serum separator tube (SST) or plain red top tube
- Units
- not specified
- Ref low
- 0.2
- Ref high
- 0.6
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- ≥ 0 years
- Method
- Spectrophotometric measurement using p-nitrophenyl phosphate substrate with isoenzyme separation by electrophoresis or lectin precipitation
- CPT
- 84075 (Alkaline phosphatase, total) with 84080 (Isoenzyme procedures)
- SNOMED
- 271508006
- Specimen volume
- 0.5-1.0 mL serum minimum
- Stability
- Room temperature: 7 days; Refrigerated (2-8°C): 7 days; Frozen (-20°C): 30 days. Avoid repeated freeze-thaw cycles.
- Hemolysis max
- 50
- Lipemia max
- 300
- Icterus max
- 20
- TAT
- 24–72 hours
- Order
- routine
What is this test?
The Alkaline Phosphatase (Liver) test measures the amount of liver-specific alkaline phosphatase enzyme in your blood serum or plasma. Alkaline phosphatase (ALP) is an enzyme found in various tissues throughout your body, including the liver, bones, intestines, and kidneys. This specific test focuses on the isoenzyme that originates primarily from the liver, helping doctors determine whether an elevated ALP level is due to liver problems or other causes.
When combined with the total ALP test, doctors can calculate the liver-to-total ALP ratio, which provides additional diagnostic information about whether the source of elevated ALP is hepatic (liver-related) or non-hepatic (such as bone disease).
Reference range
0.2-0.6not specified
No fasting or special preparation required
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Elevated liver ALP levels may indicate: Hepatitis (viral or alcoholic), Cirrhosis, Bile duct obstruction or cholestasis, Gallstones, Liver tumors or metastases, Primary biliary cholangitis, or Drug-induced liver injury.
Low ALP levels are less common but may be seen in: Malnutrition, zinc deficiency, hypothyroidism, or certain genetic disorders.
The test is typically ordered alongside other liver function tests (ALT, AST, GGT, bilirubin) to get a complete picture of liver health. It is also useful in differentiating between liver and bone causes of elevated ALP when total ALP is elevated.
Frequently asked questions
Do I need to fast before this test?
What is a normal liver ALP level?
Can medications affect my ALP results?
Is a high ALP level always serious?
How is the liver ALP different from total ALP?
Sources
- 1
- 2
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 10, 2026. · Read our editorial policy