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Alpothercfrserpl

Published: July 31, 2026Updated: August 16, 2026

The alkaline phosphatase test measures the level of this enzyme in your blood to help evaluate liver and bone health.

Quick summary

{"ALP is an enzyme found mainly in the liver and bones","High ALP levels may indicate liver disease or bone disorders","The test requires a simple blood draw","Results are often compared with other liver function tests"}

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
26010-9
Short code
ALP fraction/total ratio
Synonyms
ALP Other CFr SerPl
Category
chemistry
Sample
serum
Container
SST (Serum Separator Tube) or plain red top tube
Units
not specified
Ref low
44
Ref high
147
Fasting
false
Population
adult
Sex
all
Age range
0–120 years
Method
Electrophoresis, Chromatography, or Immunoassay for ALP isoenzyme fractionation
CPT
84075
SNOMED
271565004
Specimen volume
0.5-1 mL serum minimum
Stability
Room temperature: 8 hours; Refrigerated (2-8°C): 7 days; Frozen (-20°C): 30 days. Protect from light.
Hemolysis max
50
Lipemia max
300
Icterus max
20
TAT
24–72 hours
Order
routine

What is this test?

The alkaline phosphatase (ALP) test measures the amount of alkaline phosphatase enzyme in your blood. ALP is found in various tissues throughout the body, particularly in the liver, bones, intestines, and kidneys. Because different organs produce different forms (isoenzymes) of ALP, the test can help doctors determine if elevated levels are coming from the liver or the bones.

Reference range

44-147 U/Lnot specified

Specimen: serum

No special preparation or fasting required

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Elevated ALP levels may indicate liver problems such as bile duct obstruction, hepatitis, cirrhosis, or liver disease. It can also signal bone disorders including Paget's disease, osteomalacia, bone healing fractures, or bone tumors. High ALP is normal in children and adolescents due to bone growth, and in pregnant women due to the placenta producing ALP. Low ALP levels are less common but may indicate malnutrition, zinc deficiency, or rare conditions like hypophosphatasia.

Frequently asked questions

Do I need to fast before the ALP test?
Typically, you do not need to fast before an ALP test. However, follow your healthcare provider's specific instructions, as they may request fasting if other tests are being done simultaneously.
What are normal ALP levels?
Normal adult ALP levels typically range from 20 to 140 U/L (units per liter), but this can vary by laboratory. Children and pregnant women normally have higher levels due to bone growth and placental ALP production.
Can medications affect ALP results?
Yes, certain medications can affect ALP levels. Birth control pills, some antibiotics, and drugs for seizures or diabetes may alter results. Always inform your doctor about all medications and supplements you are taking.
Is the ALP test painful?
The test involves a routine blood draw. You may feel a brief sting or pinch when the needle is inserted, but the discomfort is minimal and temporary.
  1. 1
    MedlinePlus - Alkaline PhosphataseSource
  2. 2
    May Clinic - Alkaline PhosphataseSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy