What is this test? The Placental Alkaline Phosphatase (PLAP) test measures the amount of a specific enzyme in your blood. Alkaline phosphatase is an enzyme found throughout the body, but the placental type (PLAP) is produced primarily by the placenta during pregnancy. This test detects and measures the placental variant of alkaline phosphatase in your serum or plasma. Why is this test performed? Your healthcare provider may order this test to assess placental function and health during pregnancy. The placenta is crucial for providing nutrients and oxygen to your growing baby, and measuring PLAP levels offers insight into how well the placenta is working. In some cases, this test may also help evaluate certain tumors that can produce PLAP, such as some types of ovarian or testicular cancers. How is the test done? A healthcare professional will draw a small sample of blood from a vein in your arm and send it to a laboratory for analysis. The procedure is quick and usually takes only a few minutes. You may feel slight discomfort or notice bruising at the puncture site, but this typically resolves quickly. What do the results mean? PLAP levels normally increase during pregnancy as the placenta grows and develops. Your healthcare provider will interpret your results based on your specific situation, including how far along you are in your pregnancy. Abnormally high or low levels may require further investigation, and results should always be considered alongside your overall health and other diagnostic information. Do I need to fast before this test? Typically, no fasting is required for the PLAP test. However, always follow your healthcare provider's specific instructions, and ask for guidance if other blood tests scheduled the same day require fasting. Is this test safe during pregnancy? Yes, this test is considered safe during pregnancy. It simply involves drawing a blood sample, similar to other routine blood tests performed during prenatal care, and poses no risk to you or your baby. What could cause elevated PLAP levels? Elevated PLAP levels during pregnancy are typically normal as the placenta develops. However, significantly elevated levels may indicate placental abnormalities or, in rare cases, certain tumors. Your healthcare provider will interpret your results based on your specific circumstances. How often will I need this test? The frequency of PLAP testing varies depending on your individual situation. Your healthcare provider will determine if and when repeat testing is necessary based on your pregnancy progress and any concerns about placental function.
A blood test that measures the level of placental alkaline phosphatase, an enzyme made by the placenta during pregnancy.
{"PLAP is an enzyme made by the placenta during pregnancy","The test helps monitor placental health and function","Elevated levels may indicate certain pregnancy complications or, rarely, tumors","It is performed on a blood sample (serum)","Results are typically available within a few days"}
Key facts at a glance
- LOINC
- 1780-6
- Short code
- ALP Plac SerPl-cCnc
- Synonyms
- ALP Plac SerPl-cCnc
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- not specified
- Ref low
- 0
- Ref high
- 2
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 84075
- SNOMED
- 27550007
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What is this test?
The Placental Alkaline Phosphatase (PLAP) test measures the amount of a specific enzyme in your blood. Alkaline phosphatase is an enzyme found throughout the body, but the placental type (PLAP) is produced primarily by the placenta during pregnancy. This test specifically detects and measures the placental variant of alkaline phosphatase in your serum or plasma.
Why is this test performed?
Your healthcare provider may order this test to assess placental function and health during pregnancy. The placenta is crucial for providing nutrients and oxygen to your growing baby. By measuring PLAP levels, doctors can get insights into how well the placenta is functioning. In some cases, this test may also be used to help evaluate certain tumors that can produce PLAP, such as some types of ovarian or testicular cancers.
How is the test done?
A healthcare professional will draw a small sample of blood from a vein in your arm. This sample will be sent to a laboratory for analysis. The procedure is quick and usually takes only a few minutes. You may experience slight discomfort or bruising at the puncture site, but this typically resolves quickly.
What do the results mean?
PLAP levels normally increase during pregnancy as the placenta grows and develops. Your healthcare provider will interpret your results based on your specific situation, including how far along you are in your pregnancy. Abnormally high or low levels may require further investigation. It's important to remember that test results should always be interpreted in context with your overall health and other diagnostic information.
Reference range
0-2 U/Lnot specified
No fasting or special preparation required
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
The Placental Alkaline Phosphatase test is primarily used to monitor placental function during pregnancy. Abnormal PLAP levels may suggest placental insufficiency, where the placenta cannot adequately support the growing fetus. In non-pregnant individuals, elevated PLAP may rarely indicate certain tumors, particularly germ cell tumors of the ovaries or testes. The test is often used in conjunction with other laboratory tests and clinical assessments to provide a complete picture of placental or maternal health.
Frequently asked questions
Do I need to fast before this test?
Is this test safe during pregnancy?
What could cause elevated PLAP levels?
How often will I need this test?
Sources
- 1
- 2
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy