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Antiphospholipid Antibody, IgM, Serum/Plasma — Qualitative

Published: August 9, 2026Updated: August 16, 2026

Detects IgM antiphospholipid antibodies in serum or plasma to help evaluate autoimmune clotting risk.

Quick summary

["A positive result can support an antiphospholipid antibody evaluation, but it must be interpreted with other tests and your medical history."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
73536-5
Short code
Alpraz ind plt IgM SerPl Ql FC
Synonyms
Alpraz ind plt IgM SerPl Ql FC
Category
liver
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
44
Ref high
147
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
flow-cytometry
CPT
84075
SNOMED
27550007
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

This blood test checks for IgM antiphospholipid antibodies, which are immune proteins that can interfere with blood clotting. The result is reported as positive, negative, or possibly indeterminate.

Why might I need this test?

Your clinician may order it when evaluating unexplained blood clots, pregnancy losses, or symptoms of an autoimmune condition. It may also be used to monitor certain autoimmune disorders.

How is the test performed?

A blood sample is collected, and the laboratory examines the serum or plasma for IgM antiphospholipid antibodies. The exact laboratory method may vary, and results are often considered alongside related antibody tests.

How do I prepare for the test?

No special preparation is usually required, and fasting is generally unnecessary. Tell the healthcare professional if you are pregnant, have an infection, or take blood-thinning medicines, because these factors can affect interpretation.

Reference range

Adult: 44-147 U/LN/A

Specimen: serum

No special preparation required. Avoid fatty meals before the test if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

A positive result may occur in antiphospholipid syndrome, other autoimmune diseases, some infections, or certain medication use. It may also be temporary. One positive result does not establish antiphospholipid syndrome; your clinician may need repeat testing, additional antibody or lupus anticoagulant tests, and your clinical history.

Short name

Antiphospholipid IgM antibody

Frequently asked questions

Does a positive result mean I have antiphospholipid syndrome?
Not by itself. The diagnosis usually requires compatible clinical findings and repeated or confirmatory laboratory results.
Can this test be negative even if I have a clotting disorder?
Yes. A single negative test does not exclude every form of antiphospholipid syndrome or other clotting condition, so follow-up testing may be needed.
Are other antiphospholipid antibody tests needed?
Often, yes. Your clinician may also check IgG antibodies and lupus anticoagulant to provide a more complete assessment.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy