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Serum Concentration of Aminoglycosides (e.g., Gentamicin, Tobramycin, Amikacin)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of certain antibiotic drugs (aminoglycosides) in your blood. These drugs are used to treat serious bacterial infections but can cause side effects if levels are too high.

Quick summary

["This test helps ensure your antibiotic dose is safe and effective."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
100041-3
Short code
Aminoglycoside Susc Islt
Synonyms
Aminoglycoside Susc Islt
Category
glucose
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test if you’re receiving aminoglycoside antibiotics, such as gentamicin or tobramycin, to monitor your blood levels. This helps prevent toxicity while ensuring the drug remains effective against infections.

What Does the Test Measure?

The test measures the concentration of aminoglycoside antibiotics in your serum (blood plasma). Commonly tested drugs include gentamicin, tobramycin, and amikacin. Results help guide dosing and timing of medication.

How Is the Test Performed?

A blood sample is drawn from a vein, usually in your arm. The sample is sent to a lab for analysis using a method like **immunoassay** or **high-performance liquid chromatography (HPLC)** to detect and quantify the antibiotic.

What Do Results Mean?

Results are typically reported in micrograms per milliliter (mcg/mL) or milligrams per liter (mg/L). Interpretation depends on the specific antibiotic and your medical condition. Your provider will discuss these results with you.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

High levels of aminoglycosides can cause kidney damage, hearing loss, or nerve damage. Low levels may mean the infection isn’t fully treated. Regular monitoring helps balance effectiveness and safety.

Short name

Aminoglycoside Levels

Frequently asked questions

When should I expect results?
Results are usually available within 24 to 48 hours, depending on lab processing times. Your provider will contact you once they’re ready.
What happens if my levels are too high?
If levels are dangerously high, your provider may adjust your medication schedule, reduce the dose, or switch to a different antibiotic. They’ll work with you to keep levels safe.
Can I eat or drink before this test?
You can eat and drink normally unless instructed otherwise. Avoid caffeine or alcohol before the draw, as they may affect lab results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy