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Understanding Your Laboratory Test: What It Is, Why Your Doctor Ordered It, and How to Prepare with Confidence

Published: August 9, 2026Updated: August 17, 2026

A blood ammonia test measures the amount of ammonia in your blood to evaluate liver function and diagnose conditions affecting ammonia metabolism.

Quick summary

{"Ammonia is a waste product that healthy livers process and remove from the blood","Elevated levels may indicate liver disease, hepatic encephalopathy, or certain metabolic disorders","The test requires a blood sample, typically drawn after fasting","Certain medications and diet can affect test results","Results help doctors diagnose and monitor liver-related conditions"}

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
20683-9
Short code
Ammonia Ingesta-mCnc
Synonyms
Ammonia Ingesta-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Critical range
— – 200 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

This laboratory test measures specific substances in a sample of your blood, urine, or other body fluid to help your healthcare provider evaluate how well your body is functioning and to detect possible health conditions.

A blood ammonia test measures the level of ammonia in your bloodstream. Ammonia is a waste product formed when proteins are broken down in your body. Normally, your liver converts ammonia into urea, which is then excreted by your kidneys. This test helps doctors assess how well your liver is functioning and whether ammonia is building up in your blood.

Your doctor may order this test as part of a routine checkup, to help diagnose the cause of symptoms you are experiencing, to monitor an ongoing condition, or to see how well a treatment is working over time.

Your doctor may order this test if you have symptoms of liver problems, such as confusion, drowsiness, or shaking (tremor). It is commonly used to diagnose and monitor conditions like hepatic encephalopathy, liver failure, Reye syndrome, and certain inherited metabolic disorders. The test may also be used to evaluate the effectiveness of treatment for these conditions.

Preparation depends on the type of test being performed. Some tests require fasting for 8 to 12 hours, so you may be told to avoid all food and drinks except water. Always follow the specific instructions from your healthcare provider, and tell them about any medications or supplements you take.

Follow these preparation guidelines for accurate results: Fast for 8-12 hours before the test (usually overnight). Avoid smoking before the test, as smoking can increase ammonia levels. Inform your doctor about all medications you are taking, as some drugs can affect test results. Avoid strenuous exercise before the test, as exercise can temporarily raise ammonia levels. Your doctor may provide additional specific instructions.

During the test, a trained professional will collect the required sample, usually by drawing a small amount of blood from a vein in your arm with a thin needle. The procedure typically takes only a few minutes, and you may feel a brief pinch or sting before a small bandage is placed over the site.

A healthcare professional will draw a blood sample from a vein in your arm using a small needle. You may feel a brief pinch or stinging sensation. The blood sample is placed in a special tube and sent to a laboratory for analysis. The test is generally quick and takes only a few minutes. After the blood draw, you may have slight bruising or soreness at the needle site, but this usually resolves quickly.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Elevated blood ammonia levels (hyperammonemia) can indicate liver dysfunction or failure, as the liver cannot properly remove ammonia from the blood. High levels are commonly associated with hepatic encephalopathy, a condition where liver disease affects brain function, causing confusion, personality changes, and in severe cases, coma. Other conditions that may cause elevated ammonia include Reye syndrome, certain genetic metabolic disorders, kidney failure, and severe infections. Extremely high ammonia levels require immediate medical treatment.

Normal ammonia levels vary by laboratory but are typically between 15-45 mcg/dL (micromoles per liter). Your doctor will interpret your results based on your overall health, symptoms, and other test results. Slightly elevated levels may require monitoring, while significantly elevated levels often indicate a need for urgent medical intervention.

Frequently asked questions

Does the test hurt?
You may feel a brief pinch or sting when the needle is inserted to draw blood. This is typically mild and lasts only a moment. Some people may experience slight bruising or soreness afterward, but serious discomfort is uncommon.
How long does it take to get results?
Results are usually available within 1-2 days, though this may vary depending on the laboratory. Your healthcare provider will contact you with the results or discuss them at your follow-up appointment.
What happens if my ammonia levels are high?
High ammonia levels indicate that your body is not properly removing this waste product. Your doctor will determine the cause and appropriate treatment, which may include dietary changes, medications to reduce ammonia production, or treatment for underlying liver disease. In severe cases, hospitalization may be necessary.
Can I eat before the test?
No, you should typically fast for 8-12 hours before the test. Eating, especially high-protein foods, can temporarily increase ammonia levels and affect the accuracy of the results. Follow your doctor's specific fasting instructions.
Are there any risks with this test?
The risks are minimal and similar to any standard blood draw. These may include slight bleeding, bruising, or infection at the needle site. In rare cases, some people may feel dizzy or faint during or after the blood draw.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy