Understanding Your Laboratory Test: What It Is, Why Your Doctor Ordered It, and How to Prepare with Confidence
A blood ammonia test measures the amount of ammonia in your blood to evaluate liver function and diagnose conditions affecting ammonia metabolism.
{"Ammonia is a waste product that healthy livers process and remove from the blood","Elevated levels may indicate liver disease, hepatic encephalopathy, or certain metabolic disorders","The test requires a blood sample, typically drawn after fasting","Certain medications and diet can affect test results","Results help doctors diagnose and monitor liver-related conditions"}
Key facts at a glance
- LOINC
- 20683-9
- Short code
- Ammonia Ingesta-mCnc
- Synonyms
- Ammonia Ingesta-mCnc
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Critical range
- — – 200 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
This laboratory test measures specific substances in a sample of your blood, urine, or other body fluid to help your healthcare provider evaluate how well your body is functioning and to detect possible health conditions.
A blood ammonia test measures the level of ammonia in your bloodstream. Ammonia is a waste product formed when proteins are broken down in your body. Normally, your liver converts ammonia into urea, which is then excreted by your kidneys. This test helps doctors assess how well your liver is functioning and whether ammonia is building up in your blood.
Your doctor may order this test as part of a routine checkup, to help diagnose the cause of symptoms you are experiencing, to monitor an ongoing condition, or to see how well a treatment is working over time.
Your doctor may order this test if you have symptoms of liver problems, such as confusion, drowsiness, or shaking (tremor). It is commonly used to diagnose and monitor conditions like hepatic encephalopathy, liver failure, Reye syndrome, and certain inherited metabolic disorders. The test may also be used to evaluate the effectiveness of treatment for these conditions.
Preparation depends on the type of test being performed. Some tests require fasting for 8 to 12 hours, so you may be told to avoid all food and drinks except water. Always follow the specific instructions from your healthcare provider, and tell them about any medications or supplements you take.
Follow these preparation guidelines for accurate results: Fast for 8-12 hours before the test (usually overnight). Avoid smoking before the test, as smoking can increase ammonia levels. Inform your doctor about all medications you are taking, as some drugs can affect test results. Avoid strenuous exercise before the test, as exercise can temporarily raise ammonia levels. Your doctor may provide additional specific instructions.
During the test, a trained professional will collect the required sample, usually by drawing a small amount of blood from a vein in your arm with a thin needle. The procedure typically takes only a few minutes, and you may feel a brief pinch or sting before a small bandage is placed over the site.
A healthcare professional will draw a blood sample from a vein in your arm using a small needle. You may feel a brief pinch or stinging sensation. The blood sample is placed in a special tube and sent to a laboratory for analysis. The test is generally quick and takes only a few minutes. After the blood draw, you may have slight bruising or soreness at the needle site, but this usually resolves quickly.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Elevated blood ammonia levels (hyperammonemia) can indicate liver dysfunction or failure, as the liver cannot properly remove ammonia from the blood. High levels are commonly associated with hepatic encephalopathy, a condition where liver disease affects brain function, causing confusion, personality changes, and in severe cases, coma. Other conditions that may cause elevated ammonia include Reye syndrome, certain genetic metabolic disorders, kidney failure, and severe infections. Extremely high ammonia levels require immediate medical treatment.
Normal ammonia levels vary by laboratory but are typically between 15-45 mcg/dL (micromoles per liter). Your doctor will interpret your results based on your overall health, symptoms, and other test results. Slightly elevated levels may require monitoring, while significantly elevated levels often indicate a need for urgent medical intervention.
Frequently asked questions
Does the test hurt?
How long does it take to get results?
What happens if my ammonia levels are high?
Can I eat before the test?
Are there any risks with this test?
Sources
- 1
- 2
- 3ARUP Consult - AmmoniaSource
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy