Skip to content

Understanding Your Medical Test: A Patient Guide to What It Is, Why It Is Done, and What to Expect

Published: August 9, 2026Updated: August 16, 2026

This test detects the presence of amphetamine and methamphetamine in your blood to monitor medication use or screen for illegal drug exposure.

Quick summary

{"This test checks for stimulants like amphetamine and methamphetamine in your blood","It is used to monitor prescription ADHD medications or detect illegal drug use","Results are confirmed using specialized laboratory methods","A positive result may have legal and employment implications","The test requires a blood sample drawn from a vein"}

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
75644-5
Short code
Amphet+Methamphet Bld Ql Cfm
Synonyms
Amphet+Methamphet Bld Ql Cfm
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
confirm
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

This test is a medical procedure that helps your healthcare provider check how your body is working. It can be used to look for signs of disease, confirm or rule out a diagnosis, or keep track of a condition you already have. Your provider will explain what the test measures and how it fits into your overall care plan.

The Amphetamine/Methamphetamine blood test is a confirmatory laboratory test that detects whether amphetamine and methamphetamine are present in your bloodstream. These are stimulant drugs that affect the central nervous system. The test uses sophisticated methods to accurately identify and confirm the presence of these substances.

You may need this test if you have symptoms that need a closer look, if you are due for routine screening, or if you have a condition that requires regular monitoring. It can also help your provider choose a treatment, check whether your current treatment is working, or watch for possible side effects over time.

Your healthcare provider may order this test for several reasons: to monitor proper use of prescription stimulant medications (such as those used to treat ADHD or narcolepsy), to verify abstinence from illegal stimulant drugs as part of a treatment program, for pre-employment or legal drug screening, or to investigate symptoms that may be related to drug use or overdose.

How the test is performed depends on the type ordered, but most tests are simple and done in an office, clinic, or hospital by trained staff. You may be asked to prepare in advance, such as fasting or pausing certain medicines. The test itself is usually quick, and your care team will guide you through each step and answer your questions.

A healthcare professional will draw a small sample of blood from a vein in your arm using a needle. The blood sample is then sent to a laboratory where it undergoes confirmatory testing using specialized techniques that can accurately identify and measure the presence of amphetamine and methamphetamine.

Your results show whether your values fall within the normal range for this test. Normal results can be reassuring, while abnormal results do not always mean something serious. Your provider will review the results with you, explain what they mean in the context of your overall health, and discuss any follow-up testing or treatment that may be needed.

A 'negative' result means no amphetamine or methamphetamine was detected in your blood at the time of testing. A 'positive' result indicates that these substances were found in your blood. If you have a valid prescription for a medication containing these drugs, inform your healthcare provider and bring your prescription documentation. Results may remain positive for several days after use, depending on the specific substance and individual metabolism.

Most people have this test without any problems, and serious complications are rare. Depending on the type of test, you might have brief discomfort, minor bruising, or slight bleeding where a needle was inserted. The risk of infection is very low. Tell your provider about allergies, bleeding problems, or medicines you take, and ask questions if you have concerns.

The risks associated with this blood test are minimal and include slight bruising at the puncture site, bleeding, or rarely, infection. These risks are similar to routine blood draws.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This test is clinically significant for monitoring compliance with prescription stimulant therapies, detecting intentional or accidental overdose of stimulant medications, identifying illicit methamphetamine or amphetamine use, and supporting addiction treatment programs. It may also be used in forensic or legal contexts where documentation of drug exposure is required. Positive results should be interpreted in conjunction with clinical history, prescription records, and physical examination findings.

Frequently asked questions

How long do these drugs stay in my blood?
Amphetamine can typically be detected in blood for about 12-24 hours after use, while methamphetamine may be detectable for 24-48 hours. However, this varies based on dosage, individual metabolism, frequency of use, and kidney/liver function.
Will a positive result show up on my medical record?
Yes, the test results become part of your permanent medical record. Depending on the reason for testing (such as employment screening or legal proceedings), results may be shared with relevant parties. Discuss confidentiality concerns with your healthcare provider.
Can ADHD medications cause a positive result?
Yes, many prescription ADHD medications contain amphetamine (such as Adderall) or methamphetamine derivatives. If you have a valid prescription, inform the testing facility before the test and provide documentation. The test can sometimes distinguish between therapeutic use and illicit use based on levels detected.
What happens if I test positive for illegal drugs?
The implications depend on why the test was ordered. For medical purposes, your healthcare provider will discuss treatment options. For legal or employment contexts, the result may be reported to the requesting party. Many states have laws protecting employees who use medical marijuana or certain substances with prescriptions.
Can second-hand exposure cause a positive result?
It is unlikely but theoretically possible in extreme, enclosed environments with high drug concentrations. Most standard exposures (being near someone using drugs) would not cause a positive result. The confirmatory test is specific enough to distinguish between actual use and environmental exposure in most cases.
  1. 1
  2. 2
  3. 3

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy