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Amylaseamnccnc

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of amylase enzyme in amniotic fluid to assess fetal development and health.

Quick summary

{"Amylase in amniotic fluid is produced by the fetal pancreas and salivary glands","Elevated levels may indicate fetal digestive system abnormalities","The test helps evaluate fetal maturity and detect potential developmental issues","Sample is collected through amniocentesis","Results are interpreted alongside other prenatal tests"}

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
14392-5
Short code
Amylase Amn-cCnc
Synonyms
Amylase Amn-cCnc
Category
chemistry
Sample
fluid
Container
Sterile tube
Units
N/A
Critical range
— – 500 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
2-5 mL
Stability
Room temperature: 2h, Refrigerated: 24h
Hemolysis max
300
TAT
4–24 hours
Order
routine

What is this test?

The amniotic fluid amylase test measures the amount of amylase enzyme in the amniotic fluid that surrounds your baby during pregnancy. Amylase is a digestive enzyme produced by the fetal pancreas and salivary glands. This test is part of prenatal screening to evaluate fetal development and detect potential health issues.

How is the test performed?

A healthcare provider will collect a small sample of amniotic fluid from your uterus using a thin needle guided by ultrasound. This procedure is called amniocentesis. The sample is then sent to a laboratory where the amylase level is measured.

What do the results mean?

Amylase levels in amniotic fluid normally increase as pregnancy progresses, particularly after 36 weeks. Abnormally high or low levels may require further investigation. Your healthcare provider will interpret your results based on your pregnancy stage and other test findings.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Frequently asked questions

Is amniocentesis safe?
Amniocentesis is generally considered safe when performed by experienced healthcare providers. The procedure carries a small risk of complications such as infection, bleeding, or preterm labor. Your healthcare provider will discuss the risks and benefits with you.
Does this test tell me if my baby has Down syndrome?
While abnormal amylase levels may be associated with certain chromosomal conditions like Down syndrome, this test alone cannot diagnose genetic disorders. It is often used in combination with other screening and diagnostic tests for a more complete assessment.
When is this test typically performed?
The test is usually performed in the second or third trimester of pregnancy, typically after 15-20 weeks gestation, when there are specific clinical concerns about fetal development.
Will I need to fast before the test?
No fasting is required for this test. However, you should follow your healthcare provider's specific instructions regarding the procedure.
  1. 1
    Mayo Clinic - AmniocentesisSource
  2. 2
    March of Dimes - Prenatal TestingSource
  3. 3
    ACOG - AmniocentesisSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy