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Amylase and Lipase, Serum/Plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures two enzymes produced by the pancreas: amylase and lipase. These enzymes help break down food in your digestive system. High levels may signal pancreatic or other digestive issues.

Quick summary

["High levels can signal possible pancreatic problems or other digestive disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
72272-8
Short code
Amylase+lipase Pnl SerPl
Synonyms
Amylase+lipase Pnl SerPl
Category
glucose
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Critical range
— – 500 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test to check for conditions affecting your pancreas, such as pancreatitis, pancreatic cancer, or blockages in the bile ducts. It can also help diagnose digestive disorders or rule out other causes of abdominal pain, nausea, or vomiting.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for 8–12 hours before the test if your doctor recommends it. Bring any medications you’re taking, as some may affect results.

What the Test Involves

A healthcare provider will draw blood from a vein in your arm. You may feel a slight pinch, but it usually takes only a few minutes. The blood sample is sent to a lab for analysis.

What the Results Mean

Amylase and lipase levels can vary based on health, diet, and medications. Elevated results often indicate inflammation, infection, or structural issues in the pancreas or digestive tract. Your doctor will interpret the results in the context of your symptoms and medical history.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Pancreatic Enzyme Test

Frequently asked questions

What causes elevated amylase and lipase levels?
Common causes include pancreatitis (inflammation of the pancreas), gallbladder disease, kidney problems, or certain medications. Other possible triggers include severe abdominal pain, vomiting, or trauma to the abdomen.
Can diet or medications affect these test results?
Yes, certain foods (like fatty meals) or medications (such as NSAIDs or some antibiotics) may temporarily influence enzyme levels. Always inform your doctor about all medications and recent dietary changes.
How long does it take to get results?
Results are typically available within 24–48 hours, depending on your lab’s processing time. Your doctor will discuss the findings with you during your follow-up visit.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy