Complete Blood Count (CBC)
This test measures amylase enzyme levels in body fluid after receiving Sincalide, a medication that stimulates the pancreas to produce digestive enzymes for diagnostic evaluation.
{"Measures amylase enzyme activity in the first fluid specimen after pancreatic stimulation with Sincalide","Helps evaluate how well the pancreas is functioning","Sincalide mimics the hormone cholecystokinin (CCK) to trigger pancreatic enzyme release","Used to diagnose pancreatic disorders such as pancreatitis or pancreatic insufficiency","Blood (serum) sample is collected after Sincalide administration"}
Key facts at a glance
- LOINC
- 35346-6
- Short code
- Amylase sp1 p sincalide Fld-cCnc
- Synonyms
- Amylase sp1 p sincalide Fld-cCnc
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Critical range
- — – 500 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What is this test?
The Amylase test after Sincalide stimulation measures the amount of amylase enzyme in your body fluid (typically blood/serum) after you receive Sincalide. Sincalide is a synthetic version of a hormone called cholecystokinin (CCK) that normally tells your pancreas to release digestive enzymes. By stimulating the pancreas with Sincalide, doctors can see how well your pancreas is working and whether it responds properly to a demand for enzyme production.
Why do I need this test?
Your healthcare provider may order this test if you have symptoms suggesting a pancreatic problem, such as abdominal pain, nausea, vomiting, or digestive issues. It helps doctors determine if your pancreas is producing enzymes normally or if there is inflammation, obstruction, or other dysfunction. This test is often part of a comprehensive evaluation of pancreatic health.
How is the test performed?
First, you will receive Sincalide through an injection (usually into a vein). After a specific period of time (typically 10-30 minutes), a blood sample will be drawn from your arm. This sample is then sent to a laboratory where the amylase enzyme activity is measured. The 'first specimen post Sincalide' refers to this initial blood draw after stimulation.
How do I prepare for the test?
Your doctor will provide specific instructions. You may need to fast (not eat or drink) for 8-12 hours before the test. Certain medications, especially those affecting the pancreas or digestive system, may need to be stopped temporarily. Always inform your healthcare provider about all medications, supplements, and health conditions you have.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Elevated amylase levels after Sincalide stimulation may indicate pancreatitis (inflammation of the pancreas), pancreatic duct obstruction, or other pancreatic disorders. The test helps differentiate between pancreatic and non-pancreatic causes of abdominal symptoms.
Low or absent amylase response after Sincalide stimulation may suggest pancreatic insufficiency, where the pancreas cannot produce enough digestive enzymes. This can lead to problems with food digestion and nutrient absorption.
Results are interpreted in conjunction with your clinical symptoms, other laboratory tests (such as lipase), and imaging studies to form a complete picture of your pancreatic health.
Frequently asked questions
What is Sincalide and is it safe?
How long does the entire test take?
Will I feel anything during the test?
When will I get my results?
Are there any risks associated with this test?
Sources
- 1
- 2
- 3
- 4
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy