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Amylasesp5psincalidefldccnc

Published: August 9, 2026Updated: August 16, 2026

This test measures amylase levels in blood after pancreatic stimulation with Sincalide to evaluate exocrine pancreatic function.

Quick summary

{"Measures amylase enzyme activity in serum after pancreatic stimulation","Assesses how well the pancreas produces digestive enzymes","Involves multiple blood samples following Sincalide administration","Helps diagnose pancreatic insufficiency and related conditions","The 5th specimen is collected to assess delayed pancreatic response"}

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
35342-5
Short code
Amylase sp5 p sincalide Fld-cCnc
Synonyms
Amylase sp5 p sincalide Fld-cCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Critical range
— – 500 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

The Amylase Post-Sincalide test measures the level of amylase—an enzyme that breaks down carbohydrates—in your blood. Sincalide is a medication that mimics the hormone cholecystokinin (CCK), which stimulates the pancreas to release digestive enzymes. By measuring amylase levels at specific intervals after Sincalide administration, doctors can assess how well your pancreas is functioning. The '5th specimen' refers to the fifth blood sample collected during the test, which helps evaluate the pancreas's delayed or sustained response to stimulation.

How is the test performed?

You will receive an injection of Sincalide, usually into a vein. Blood samples are then collected at specific time intervals (typically 30, 60, 90, 120 minutes after injection). The 5th specimen is one of these follow-up samples. The procedure takes about 2-3 hours total. You may experience mild abdominal discomfort or urge to have a bowel movement after Sincalide, as it also stimulates bowel activity.

How to prepare?

Fast for 8-12 hours before the test as instructed by your doctor. Inform your healthcare provider about all medications you are taking, especially pancreatic enzymes or medications that affect pancreatic function. Avoid alcohol before the test. Follow any specific instructions provided by your healthcare facility.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings2

Frequently asked questions

Why is Sincalide used?
Sincalide mimics the natural hormone cholecystokinin (CCK), which normally stimulates the pancreas to release digestive enzymes. By administering Sincalide, doctors can see how your pancreas responds to a standard stimulus, similar to how a stress test evaluates heart function.
Is the test painful?
The test involves an IV injection and multiple blood draws, which may cause minor discomfort or bruising at the needle site. Some patients experience brief abdominal cramping or nausea after Sincalide, but these effects are usually temporary.
How long does it take to get results?
Results are typically available within 1-3 days, depending on the laboratory. Your healthcare provider will discuss the results with you during a follow-up appointment.
Are there any risks?
The test is generally safe. Possible side effects include abdominal discomfort, nausea, flushing, or dizziness. Serious complications are rare. Inform your doctor if you have a history of gallbladder disease, intestinal obstruction, or allergies to similar medications.
  1. 1
    MedlinePlus - Pancreatic function testsSource
  2. 2
    Mayo Clinic Laboratories - AmylaseSource
  3. 3
    ARUP Consult - Pancreatic EnzymesSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy