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Anacentrosomaltitrcsfif

Published: August 9, 2026Updated: August 17, 2026

This test detects specific antibodies in the cerebrospinal fluid that may indicate autoimmune diseases affecting the brain and nervous system.

Quick summary

{"The test uses cerebrospinal fluid (CSF) collected via lumbar puncture","It detects antibodies targeting cell nuclei and centrosomes","Results help diagnose autoimmune neurological conditions","A positive result may indicate conditions like multiple sclerosis or lupus","The test uses immunofluorescence technology for detection"}

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
96927-9
Short code
ANA centrosomal Titr CSF IF
Synonyms
ANA centrosomal Titr CSF IF
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Ref low
7
Ref high
56
Critical range
— – 500 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
if
CPT
84484
SNOMED
302773008
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

What is this test?

The Centrosomal Nuclear Antibody test is a specialized blood fluid test that looks for specific antibodies in your cerebrospinal fluid (CSF). CSF is the clear liquid that surrounds and protects your brain and spinal cord. This test detects antibodies that target structures called centrosomes and cell nuclei, which are important components of your cells.

How is the sample collected?

Cerebrospinal fluid is collected through a procedure called a lumbar puncture, also known as a spinal tap. A healthcare provider inserts a thin needle into the lower back to withdraw a small amount of CSF. The procedure usually takes about 15-30 minutes. You may feel some discomfort or pressure during the insertion.

How does the test work?

The test uses a technique called immunofluorescence. The CSF sample is mixed with fluorescent dyes that attach to specific antibodies. When examined under a special microscope, any antibodies present will glow, allowing technicians to detect and measure them (titer).

Reference range

Adult males: 7-56 U/L; Adult females: 7-43 U/LN/A

Specimen: csf

No special preparation required. Avoid fatty meals before the test if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Frequently asked questions

Do I need to fast before this test?
No, fasting is not typically required for this test. However, follow any specific instructions provided by your healthcare provider.
How long does it take to get results?
Results usually take 3-7 days, as this is a specialized test performed in specialized laboratories.
Is the lumbar puncture painful?
A lumbar puncture is performed with local anesthesia, so you may feel pressure but minimal pain during the procedure. Some people experience a headache afterward, which can usually be managed with rest and fluids.
What do the titer results mean?
The titer indicates the concentration of antibodies detected. Higher titers typically suggest a stronger immune response. Your doctor will interpret these results in the context of your overall health and other test findings.
Do I need to stop medications before the test?
Inform your healthcare provider about all medications you take. Some immunosuppressant drugs may affect results. Do not stop taking prescribed medications without consulting your doctor.
  1. 1
    Mayo Clinic - Lumbar Puncture (Spinal Tap)Source
  2. 2
    National Institute of Neurological Disorders and StrokeSource
  3. 3
    ARUP Laboratories - Immunofluorescence TestingSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy