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Anachromosomalserqlif

Published: August 9, 2026Updated: August 16, 2026

A blood test that detects antinuclear antibodies targeting chromosomal proteins, used to diagnose autoimmune diseases like systemic lupus erythematosus.

Quick summary

{"This test checks for antibodies that attack the nucleus of cells","A positive result may indicate autoimmune diseases, especially lupus","Results are interpreted along with symptoms and other tests","The test uses immunofluorescence technology for detection","Follow-up testing is often needed to confirm diagnosis"}

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
53990-8
Short code
ANA chromosomal Ser Ql IF
Synonyms
ANA chromosomal Ser Ql IF
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
if
CPT
86038
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

The Chromosomal Nuclear Antibody test is a blood test that detects the presence of antinuclear antibodies (ANA) that specifically target chromosomal proteins. These antibodies are directed against the genetic material (DNA and histones) inside cell nuclei. The test uses immunofluorescence techniques to identify the characteristic staining patterns produced by these antibodies.

How is the test performed?

A healthcare professional will draw a blood sample from a vein in your arm. The sample is then sent to a laboratory where technicians will mix it with fluorescent dyes and examine it under a special microscope. The fluorescent pattern created by the antibodies helps identify the specific type of autoimmune condition present.

What do the results mean?

A positive result indicates the presence of chromosomal-targeted antinuclear antibodies. This pattern (often called homogeneous or diffuse) is commonly associated with systemic lupus erythematosus (SLE). However, a positive result does not automatically mean you have a disease—your doctor will interpret the results along with your symptoms, medical history, and other laboratory findings.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Frequently asked questions

Do I need to fast before this test?
No special preparation is typically required. You can eat and drink normally before the test. However, always follow your doctor's specific instructions.
Can medications affect the results?
Certain medications, including some antibiotics, blood pressure drugs, and anti-seizure medications, may affect test results. Inform your doctor about all medications and supplements you are taking.
Is a positive result always serious?
Not necessarily. Some healthy individuals, especially older adults, may have low levels of antinuclear antibodies without any disease. Your doctor will consider many factors before making a diagnosis.
How long does it take to get results?
Results are typically available within a few days to a week, depending on the laboratory. Your healthcare provider will contact you with the results.
Will I need other tests?
Yes, if this test is positive, your doctor will likely order additional tests such as anti-dsDNA, anti-Smith, or complement levels to confirm a diagnosis and assess disease severity.
  1. 1
    Mayo Clinic - Antinuclear antibody (ANA) testSource
  2. 2
    MedlinePlus - ANA testSource
  3. 3
    Arthritis Foundation - Understanding ANA ResultsSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy