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Anamsmtpcar

Published: August 9, 2026Updated: August 16, 2026

This test measures nuclear antibodies (ANA) in the fluid around the heart (pericardial fluid) to help determine if an autoimmune condition is causing pericarditis.

Quick summary

{"The test checks for autoimmune antibodies in heart fluid","It helps doctors find the cause of pericarditis (heart lining inflammation)","A positive result may indicate lupus, rheumatoid arthritis, or other autoimmune diseases","The fluid is collected using a needle procedure called pericardiocentesis","Results are interpreted alongside other clinical findings"}

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
109836-7
Short code
ANA Msmt Pcar
Synonyms
ANA Msmt Pcar
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
86038
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

A nuclear antibody (ANA) test in pericardial fluid looks for specific proteins called antinuclear antibodies in the fluid that surrounds your heart. These antibodies are normally produced by your immune system to fight harmful substances, but sometimes they mistakenly attack your body's own cells. When these antibodies are found in pericardial fluid, it may indicate that an autoimmune disorder is causing inflammation of the pericardium (the sac around your heart).

How is the sample collected?

Pericardial fluid is collected through a procedure called pericardiocentesis. During this procedure, a doctor inserts a thin needle through your chest wall into the pericardial sac to withdraw fluid. The area will be numbed with local anesthesia to minimize discomfort. This procedure is typically done while monitoring your heart with ultrasound (echocardiography) for safety.

Why might I need this test?

Your doctor may order this test if you have symptoms of pericarditis that are severe, recurring, or not responding to standard treatment. Symptoms include sharp chest pain that worsens with breathing, fever, and difficulty breathing. Finding nuclear antibodies in the fluid can help determine if an autoimmune condition is the underlying cause, which would guide treatment with immunosuppressive medications rather than just anti-inflammatory drugs.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Frequently asked questions

Is this test painful?
The area is numbed with local anesthesia during pericardiocentesis, so you should feel minimal pain. You may feel some pressure or discomfort. After the procedure, you may have mild soreness at the needle site.
How long does it take to get results?
Results typically take 1-3 days, as the fluid needs special laboratory analysis. Your doctor will call you or schedule a follow-up visit to discuss the results.
What do positive results mean?
A positive result suggests your pericarditis may be caused by an autoimmune condition. However, this is not always definitive—your doctor will interpret results alongside your symptoms, other test results, and medical history.
Are there risks to having this test?
Risks of pericardiocentesis include bleeding, infection, puncturing the heart or lungs, and irregular heartbeats. These complications are uncommon, and the procedure is done under close monitoring for safety.
Do I need to prepare anything before the test?
Your doctor will give you specific instructions. You may need to fast or adjust medications. Inform your doctor about blood thinners or bleeding problems. An echocardiogram is usually done before the procedure to assess the fluid amount.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy